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Next Generation Components and Systems for Biomedical Imaging

下一代生物医学成像组件和系统

基本信息

批准号：
EP/I018328/1
负责人：
Richard Hogg
金额：
$ 133.58万
依托单位：
University of Sheffield
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2011
资助国家：
英国
起止时间：
2011 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=EP%2FI018328%2F1
关键词：
Next Generation Components Systems Biomedical

项目摘要

Optical coherence tomography (OCT) is a new optical bio-imaging tool which is firmly established in ophthalmology and rapidly emerging in areas such as cancer detection, wound monitoring, cardiovascular medicine and tissue engineering. The performance of OCT depends critically on the performance of the light source and the technique's penetration into the wider medical arena is being delayed by the current generation of sources. Our partnership brings together a multidisciplinary team with demonstrated expertise in the entire OCT development chain from photonic device technologists, through biomedical optics researchers, commercial OCT systems manufacturers and clinical end-users into a co-ordinated programme to address this bottleneck. We aim to develop a new generation of light sources which will achieve not only a price/performance breakthrough but also enable much greater system miniaturisation and ruggedness. The new light sources will be evaluated in an active OCT research laboratory and also offered for evaluation by our commercial partners. Next generation OCT imaging systems will be realised by developing optical components and laser systems which will redefine the state-of-the-art with regard to factors such as output power, emission band-width, tuneability of linewidth, sweep speed, and incorporate design features to simplify the OCT system and reduce cost. The research is vertically integrated from the development of new epitaxial techniques, modification of semiconductor materials, device design and fabrication technologies, development of swept laser systems, and their assessment and implementation in OCT systems studying real biological samples.

光学相干断层扫描（OCT）是一种新的光学生物成像工具，它在眼科学中牢固确立，并在癌症检测、伤口监测、心血管医学和组织工程等领域迅速兴起。OCT的性能关键取决于光源的性能，并且该技术向更广泛的医学竞技场的渗透被当前一代光源延迟。我们的合作伙伴关系汇集了一个多学科团队，他们在整个OCT开发链中具有专业知识，从光子器件技术专家，到生物医学光学研究人员，商业OCT系统制造商和临床最终用户，共同参与一个协调计划，以解决这一瓶颈。我们的目标是开发新一代的光源，不仅实现价格/性能的突破，而且实现更大的系统集成和坚固性。新光源将在一个活跃的OCT研究实验室进行评估，并由我们的商业合作伙伴进行评估。下一代OCT成像系统将通过开发光学组件和激光系统来实现，这些光学组件和激光系统将重新定义关于诸如输出功率、发射带宽、线宽调谐、扫描速度等因素的最新技术水平，并结合设计特征以简化OCT系统并降低成本。该研究是垂直整合从新的外延技术的发展，半导体材料，器件设计和制造技术的修改，扫描激光系统的发展，以及它们的评估和OCT系统研究真实的生物样品的实施。