PERIPHERAL AND CENTRAL SATIETY ACTIONS OF BOMBESIN

这项建议有三个主要目的： 首先，确定饱腹感的作用部位和传入途径 外源性蛙皮素对大鼠外周给药的作用; 其次，为了检验食物的饱腹作用在 胃至少部分地由从胃粘膜释放的蛙皮素介导。 大鼠胃; 第三，分析饱腹感的神经和/或内分泌机制 蛙皮素对大鼠下丘脑外侧注射的影响。 本文的主题是继续分析前吸收的作用 机制（特别是肽功能）在诱发 餐后饱腹感 中心目标是确定外围 控制膳食大小的机制。 这些知识应该呈现 开发基于生理学的肥胖治疗方法的机会， 治疗暴食症

This proposal has three major purposes: First, to determine the site of action and afferent pathway for the satiety action of exogenous bombesin administered perpherally in the rat; Seconds, to test the hypothesis that the satiating effect of food in the stomach is mediated, at least in part, by bombesin released from the stomach in the rat; Third, to analyze the neural and/or endocrine mechanisms of the satiety effect of lateral hypothalamic injections of bombesin in the rat. The theme is to continue the analysis of the role of preabsorptive mechanisms (especially peptide functions) in the elicitation of postprandial satiety. The central goal is to determine the peripheral mechanisms controlling meal size. This knowledge should present opportunities to develop physiologically-based treatments for obesity and for bulimia.