OSTEOARTHRITIS & OSTEOPOROSIS IN ELDERLY WOMAN

骨性关节炎是老年人活动受限的主要原因 女人。然而，几乎没有关于风险因素和后果的数据。 这种疾病在老年女性中的发病率。骨质疏松症也很常见，而且 研究表明，心脏病的风险与 骨关节炎和骨质疏松症的风险。骨量是否增加 密度是骨性关节炎发生发展的致病因素，目前尚不确定。这 这一问题尤其重要，如果采取干预措施来降低 骨质疏松症也会增加骨性关节炎的风险。最好的研究将测量 受骨性关节炎影响的关节附近的骨量。骨性关节炎的危险因素 不同的关节是不同的，提示骨性关节炎的发病机制可能 因场地而异。骨量也因个体内的解剖部位而异。 因此，我们将研究髋部骨量与髋部骨关节炎的关系。 桡骨质量与手部骨关节炎的关系，以及脊柱的骨量 与脊柱骨关节炎的关系。我们还将检查特定于以下各项的其他风险因素 手部、髋部和脊椎骨关节炎，并比较不同关节的风险因素。 这项研究利用了“骨质疏松性骨折研究”(SOF)， 9712名年龄在65岁及以上的女性已经接受了髋部X光检查， 手部，脊柱，骨量测量的半径，距骨，股骨， 和腰椎，以及许多危险因素和结果的测量 与办公自动化相关。这项研究的新数据将作为 第二次自卫队检查，一直进行到1990年底。具有以下内容的数据 已为特种部队收集的数据，加上为本研究收集的新数据将 允许我们1)测试存在反向关联的假设 在骨质疏松症和骨质疏松症之间；2)检验危险因素的假设 与骨质疏松症风险降低相关的是 增加骨关节炎的风险；3)描述髋骨骨关节炎、手部骨关节炎、 和老年女性的椎间盘退变，并描述和比较选定的 由解剖部位和类型确定的骨性关节炎亚型的危险因素 关节受累；以及4)描述疼痛和功能残疾 髋关节、手部和手部有放射性骨性关节炎的老年女性 脊椎。 我们将阅读所有9712名SOF参与者的髋关节X光片以进行髋关节骨关节炎，以及 手部和脊椎骨关节炎1500名受试者的X光片。大型特种部队 人口将产生260多例髋关节骨性关节炎。射线照相 对办公自动化的评估将包括标准的0-4级，以及 对特定异常严重程度的定量测量。这 提案要求资金阅读X光，收集少量 关于骨性关节炎风险因素和结局的新数据，并对数据进行分析。 因此，可以有效地实现本研究的目标，而不需要 组织一项新的研究。这项研究也将为以下工作奠定基础 骨性关节炎进展和转归的纵向研究 将继续跟踪队列，未来的诊所就诊包括 计划进行重复的X光片和骨密度测量。

Osteoarthritis (OA) is the leading cause of activity limitation in older women. Yet, there is little data about risk factors for and consequences of the disease in older women. Osteoporosis is also very common, and studies suggest there is an inverse association between the risk of osteoarthritis and the risk of osteoporosis. Whether increased bone density is a pathogenic factor in the development of OA is uncertain. This question is particularly important if interventions to reduce the risk of osteoporosis also increase the risk of OA. The best study would measure bone mass near joints that are affected by OA. Risk factors for OA of different joints are different, suggesting that the pathogenesis of OA may vary by site. Bone mass also varies by anatomic site within individuals. Therefore, we will study bone mass in the hip in relation to hip OA, bone mass in the radius in relation to hand OA, and bone mass in the spine in relation to spine OA. We will also examine other risk factors specific to hand, hip, and spine OA, and compare risk factors for different joints. This study takes advantage of the "Study of Osteoporotic Fractures" (SOF), a cohort of 9712 women age 65 and over who already have X rays of the hip, hand, and spine, bone mass measurements of the radius, os calcis, femur, and lumbar spine, and measurements of many risk factors and outcomes relevant to OA. New data for this study will be collected as part of the second SOF examination, in progress until late 1990. Data that have already been collected for SOF, plus new data collected for this study will allow us to 1) test the hypothesis that there is an inverse association between OA and osteoporosis; 2) test the hypothesis that risk factors associated with a decreased risk of osteoporosis are associated with an increased risk of OA; 3) describe the associations among hip OA, hand OA, and disc degeneration in older women, and to describe and compare selected risk factors for subsets of OA defined by anatomic site and pattern of joint involvement; and 4) describe the pain and functional disability experienced by older women with radiographic OA of the hips, hand, and spine. We will read the hip X rays of all 9712 SOF participants for hip OA, and the X rays of 1500 participants for hand and spine OA. The large SOF population will yield more than 260 cases of hip OA. Radiographic assessments of OA will include standard 0-4 gradings, as well as quantitative measures of the severity of specific abnormalities. This proposal requests funds to read the X rays, to collect a small amount of new data on risk factors and outcomes of OA, and to analyze the data. Thus, the objectives of this study can be achieved efficiently without organizing a new study. This study will also lay the ground work for longitudinal studies about the progression and outcome of OA; the SOF cohort will continue to be followed, and future clinic visits including repeat radiographs and bone density measurements are planned.