TAS::75 0903::TAS RECOVERY ACT CONTRACT ACTION - PROVIDING RADIOLOGIC OUTCOMES F

TAS::75 0903::TAS 恢复法案合同行动 - 提供放射学成果 F

• 批准号: 8172298
• 负责人: MICHAEL C NEVITT
• 金额: $ 193.26万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-29 至 2011-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8172298
• 关键词: Biochemical Genetics; Biochemical Markers; Biological Markers; Clinic Visits; Clinical Research; Cohort Studies; Contracts; Data; Data Quality; Data Set; Databases; Diagnosis; Disease; Economics; Epidemiology; Evaluation; Goals; Image; Incidence; Individual; Investments; Joints; Knee; Knee Osteoarthritis; Measures; Medical; Methods; Natural History; Onset of illness; Outcome; Participant; Prevalence; Reading; Records; Recovery; Research; Research Design; Research Personnel; Risk; Risk Factors; Sampling; Width; Work; base; case control; cohort; disability burden; experience; follow up assessment; follow-up; genetic risk factor; meetings; novel; success; web site

The proposed study will utilize the longitudinal knee radiographs obtained in all OAI study participants to provide structural endpoints for users of the OAI public databases by: 1) comprehensively reading all of the knee radiographs for OA prevalence, progression and incidence using Kellgren and Lawrence (K-L) grades and individual radiographic feature scores; 2) obtaining quantitative measures of joint space width in all knees of subjects in the Progression cohort and knees with OA in subjects in the Incidence cohort. The results of these assessments will be released as public use datasets through the OAI Online public website. As noted in the RFP, the OAI cohort study is a publicly available database of baseline and annual follow-up assessments in 4,796 subjects who have, or are at risk of developing, knee OA. The OAI was designed for studies of imaging, biochemical and genetic biomarkers of OA incidence and progression, and studies of the natural history and risk factors for OA. The main focus of the OAI is on the knee. Standardized knee radiographs and MRIs of the knee were performed on all subjects at baseline and repeated in all subjects who attended the follow-up clinic visits and who remained eligible for knee imaging. In order to realize the full potential of the OAI, the proposed project will provide users of the OAI public database with a standard set of variables on the prevalence, incidence and progression of radiographic knee OA (RKOA) for use in biomarker (MRI-based imaging, biochemical and genetic), risk factor and natural history studies of knee OA. To perform this work, we will enlist experienced reading centers for knee OA structural outcomes with established track records in providing high quality data for large epidemiological and clinical studies. These teams have already been tapped by the OAI to provide central image assessment data on a limited scale in the OAI Progression cohort. The current project proposes to complete these central image assessments in the Progression subcohort and extend this work to the much larger Incidence subcohort.

拟议研究将利用所有OAI研究参与者获得的纵向膝关节X线片，通过以下方式为OAI公共数据库的用户提供结构性终点： 1)使用Kellgren和Lawrence（K-L）分级和个体放射学特征评分，全面阅读所有膝关节X线片，以了解OA的患病率、进展和发病率; 2)获得进展队列中受试者的所有膝关节和发病队列中受试者的OA膝关节的关节间隙宽度的定量测量。这些评估的结果将作为公共使用数据集通过审调处在线公共网站发布。 如RFP中所述，OAI队列研究是一个公开可用的数据库，包含4，796例患有膝关节骨性关节炎或有发生膝关节骨性关节炎风险的受试者的基线和年度随访评估。审调处的设计目的是 骨关节炎发病率和进展的影像学、生物化学和遗传生物标志物研究，以及骨关节炎自然史和风险因素研究。OAI的主要重点是膝盖。标准化膝关节 在基线时对所有受试者进行膝关节X线片和MRI检查，并在参加随访诊所访视并仍符合膝关节成像条件的所有受试者中重复检查。为了充分发挥OAI的潜力，拟议项目将为OAI公共数据库的用户提供一套标准的变量，这些变量涉及放射学膝关节疾病的患病率、发生率和进展情况。 用于膝关节OA的生物标志物（基于MRI的成像、生物化学和遗传学）、风险因素和自然史研究的OA（RKOA）。为了开展这项工作，我们将招募经验丰富的膝关节骨性关节炎结构结局阅读中心，这些中心在为大型流行病学和临床研究提供高质量数据方面具有既定的记录。OAI已经利用这些团队在OAI进展队列中提供有限规模的中央图像评估数据。目前的项目建议在进展子队列中完成这些中心图像评估，并将这项工作扩展到更大的发病率子队列。