Multi-Center Osteoarthritis Study

描述（由申请人提供）：骨关节炎（OA）是最常见的 关节炎的形式，以及膝盖或臀部的疾病是导致 残疾。大多数膝关节和髋关节OA的流行病学研究都集中在 影像学疾病，但症状性OA应该是一个主要的研究重点， 预防OA，因为有症状的疾病会导致残疾， 社会和公共卫生影响。OA是可以预防的，但只有 已经确定了有限数量的大多数不可改变的风险因素，即使 虽然可改变的风险因素，如特定的活动，肌肉无力， 本体感受缺陷、微量营养素缺乏和结构性因素， 已被提出，并可能影响重大疾病的风险。预防 机会是最相关的，最有可能被那些 已经患病或患病风险最高的人。 该建议为流行病学研究引入了四种新方法， 膝骨关节炎：l. a关注症状性疾病，2.全面 风险因素的评估，包括可修改的，3。关注那些 将真正受益于预防机会，那些已经有 疾病或那些谁在高风险得到它和4.掺入 比以前使用的成像更全面和可再现 包括最先进的射线照相技术和MRI。MRI提供丰富的 关于异常情况可能影响 疾病 本研究的总体目标是纵向评价 三组因素：生物力学因素（蹲，跪，楼梯 爬山，穿高跟鞋，股四头肌无力和本体感觉 缺陷）、骨和结构因素（骨密度、骨髓和骨密度） 病变MRI）和微量营养素缺乏症（维生素C，E和D）对 在一个有症状和放射学检查的膝关节OA患者中， 以人口为基础的50至79岁男性和女性样本。虽然重点是 这个项目是膝关节骨性关节炎，我们也纳入了髋关节骨性关节炎的研究。 我们建议招募一个以社区为基础的3,000名男女样本， 患有膝关节骨性关节炎或有患骨性关节炎的高风险。高危人群包括 那些超重的人，那些有膝盖症状的人，以及那些有 膝盖受伤或手术。将对受试者进行症状评估 问卷调查，X光片和核磁共振成像并将随访36个月， 症状性或影像学OA的发展或进展。分析将 关注这些重要的危险因素与OA结局的关系。 这一大型、多方面的研究提供了明确解决的关系， 对重大疾病的发展或进展具有潜在重要风险的因素 使疾病丧失能力，并为疾病生物学提供新的见解， 预防疾病的潜在机会。

DESCRIPTION (provided by applicant): Osteoarthritis (OA) is the most common form of arthritis, and disease in the knee or hip are leading causes of disability. Most epidemiologic studies of knee and hip OA have focused on radiographic disease, but symptomatic OA should be a major focus of studies on preventing OA, because symptomatic disease causes disability and has formidable societal and public health impacts. OA is potentially preventable, but only a limited number of mostly nonmodifiable risk factors has been identified, even though modifiable risk factors such as particular activities, muscle weakness, proprioceptive deficits, micronutrient deficiencies and structural factors have been proposed and may affect substantially the risk of disease. Prevention opportunities are most relevant and are most likely to be used by those who already have disease or who are at highest risk of getting it. This proposal introduces four new approaches into the epidemiologic study of knee osteoarthritis: l.a focus on symptomatic disease, 2. a comprehensive evaluation of risk factors including modifiable ones, 3. a focus on those who would really benefit from prevention opportunities, those who already have disease or those who are at high risk of getting it and 4. the incorporation of more comprehensive and reproducible imaging than has previously been used including, state of the art radiographic techniques and MRI. MRI provides rich information on structural factors in which abnormalities may affect the risk of disease. The overall objective of this study is to evaluate longitudinally the effects of three groups of factors: biomechanical factors (squatting, kneeling, stair climbing, wearing high heeled shoes, quadriceps weakness and proprioceptive deficits), bone and structural factors (bone density, bone marrow and meniscal lesions on MRI) and micronutrient deficiencies (vitamin C, E and D) on the occurrence and progression of symptomatic and radiographic knee OA in a population-based sample of men and women aged 50 to 79. Although the focus of this project is knee OA, we also incorporate a study of hip OA. We propose to recruit a community-based sample of 3,000 men and women likely to either have knee OA or be at high risk of OA. High risk groups will include those who are overweight, those with knee symptoms and those with a history of knee injuries or operations. Subjects will be evaluated with symptom questionnaires, radiographs and MRI?s and will be followed 36 months for the development or progression of symptomatic or radiographic OA. Analyses will focus on the relation of these important risk factors and OA outcomes. This large, multifaceted study offers to address definitively the relation of potentially important risk factors to the development or progression of a major disabling disease and to provide new insights into disease biology and potential opportunities for disease prevention.