THE ROLE OF 1,25 DIHYDOXYVITAMIN D DURING FETAL LIFE
THE ROLE OF 1,25 DIHYDOXYVITAMIN D DURING FETAL LIFE
批准号:
3157622
负责人:
RICHARDUS ROSS
金额:
$10.85万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1986
资助国家:
美国
项目状态:
已结题
起止时间:
1986-01-01 至 1988-12-31
关键词:
1,25 dihydroxycholecalciferol atomic absorption spectrometry bone metabolism disorder embryo /fetus high performance liquid chromatography hypocalcemia kidney function kidney metabolism longitudinal animal study nephrectomy nutrition related tag parathyroid hormones pregnancy circulation premature infant animal radioimmunoassay respiratory gas analyzer scintillation spectrometry sheep vitamin biosynthesis vitamin metabolism vitamin therapy
中文摘要
许多早产儿在出生后的最初 24 小时内会出现低钙血症。
生活。 其中,百分之二十可能有后续的骨骼
demineralization (osteopenia, rickets, long bone fractures). 的
underlying mechanisms are unknown but may involve abnormal vitamin D
新陈代谢。 本提案旨在帮助明确
the hormonal form of vitamin D, namely, 1,25 dihydroxyvitamin D
(1,25(OH)2D) in the mineral economy of the fetus during intrauterine life.
The following specific questions will be addressed: 1) What are the
relative contributions of the fetal kidney and the placenta to fetal
circulating 1,25(OH)2D concentrations during intrauterine life? 2) 是
normal fetal circulating 1,25(OH)2D concentrations necessary for normal
宫内矿物质代谢? 3)胎盘和胎儿的骨头吗
responsive target organs for the action of 1,25(OH)2D during fetal life?
In phase I of our study, singleton sheep fetuses will be instrumented at
110 days of gestation (term 145) to determine the 1,25(OH)2D synthetic
胎儿胎盘单位的容量。 这将通过测量来完成
the fetal Production and Metabolic Clearance Rates of 1,25(OH)2D and by
measurement of the in vivo placental synthesis rate using an in vivo
胎盘灌注技术。 与妊娠相关的正常变化
血清矿物质和钙调节激素也将被评估
longitudinally from 110 days to 138 days of gestation when normal placental
将确定矿物质转移和胎儿矿物质利用率。
在我们研究的第二阶段,我们将使用双侧肾切除的胎儿
determine the impact of loss of fetal renal 1,25(OH)2D synthetic capacity
on fetal serum 1,25(OH)2D and mineral concentrations, placental mineral
转移和胎儿矿物质利用率。 根据我们之前的
研究表明,胎儿肾切除术会导致胎儿低钙血症,
高磷血症和胎儿血清 1,25(OH)2D 浓度降低。 我们
假设这些变化是由 1,25(OH)2D 介导的减少引起的
胎盘矿物质转移和正常骨矿化的破坏
通过外源性 1,25(OH)2D 疗法可以在很大程度上得到纠正。
这些综合研究将为功能性提供有价值的见解。
1,25(OH)2D 在胎儿生命中的作用,因为它与以下病因有关
早产儿低钙血症和骨脱矿。
英文摘要
Many premature infants develop hypocalcemia during the first 24 hours of
life. Of these, twenty percent may have subsequent skeletal
demineralization (osteopenia, rickets, long bone fractures). The
underlying mechanisms are unknown but may involve abnormal vitamin D
metabolism. The present proposal is designed to help clarify the role of
the hormonal form of vitamin D, namely, 1,25 dihydroxyvitamin D
(1,25(OH)2D) in the mineral economy of the fetus during intrauterine life.
The following specific questions will be addressed: 1) What are the
relative contributions of the fetal kidney and the placenta to fetal
circulating 1,25(OH)2D concentrations during intrauterine life? 2) Are
normal fetal circulating 1,25(OH)2D concentrations necessary for normal
intrauterine mineral metabolism? 3) Are the placenta and fetal bone
responsive target organs for the action of 1,25(OH)2D during fetal life?
In phase I of our study, singleton sheep fetuses will be instrumented at
110 days of gestation (term 145) to determine the 1,25(OH)2D synthetic
capacity of the fetal-placental unit. This will be done by measurement of
the fetal Production and Metabolic Clearance Rates of 1,25(OH)2D and by
measurement of the in vivo placental synthesis rate using an in vivo
placental perfusion technique. Normal gestationally related changes in
serum minerals and calcium regulating hormones will also be assessed
longitudinally from 110 days to 138 days of gestation when normal placental
mineral transfer and fetal mineral utilization rates will be determined.
In phase II of our study, we will use bilaterally nephrectomized fetuses to
determine the impact of loss of fetal renal 1,25(OH)2D synthetic capacity
on fetal serum 1,25(OH)2D and mineral concentrations, placental mineral
transfer and fetal mineral utilization rates. Based on our previous
studies, fetal nephrectomy will result in fetal hypocalcemia,
hyperphosphatemia and reduced fetal serum 1,25(OH)2D concentrations. We
hypothesize that these changes result from reduced 1,25(OH)2D-mediated
placental mineral transfer and disruption of normal bone mineralization and
will be largely corrected by treatment with exogenous 1,25(OH)2D therapy.
These combined studies will provide valuable insight into the functional
role of 1,25(OH)2D during fetal life, as it relates to the etiology of
hypocalcemia and bone demineralization in prematurity.
期刊论文(3)
专著(0)
科研奖励(0)
会议论文
Postnatal changes in serum osteocalcin and parathyroid hormone concentrations.
产后血清骨钙素和甲状旁腺激素浓度的变化。
DOI:
10.1080/07315724.1990.10720393
发表时间:
1990
期刊:
Journal of the American College of Nutrition
影响因子:
3.5
作者:
[Loughead,JL, Mimouni,F, Ross,R, Tsang,RC]
通讯作者:
Tsang,RC
Clearance of calcium across in situ perfused placentas of intrauterine growth-retarded rat fetuses.
宫内生长迟缓的大鼠胎儿原位灌注胎盘中钙的清除率。
DOI:
10.1203/00006450-198904000-00023
发表时间:
1989
期刊:
Pediatric research
影响因子:
3.6
作者:
[Mughal,MZ, Ross,R, Tsang,RC]
通讯作者:
Tsang,RC
ISOFLAVONE-RICH PASTA--CLINICAL AND COMMERCIAL POTENTIAL
-
批准号:6172946
-
项目类别:
-
资助金额:$18.97万
-
财政年份:1996
-
负责人:RICHARDUS ROSS
-
依托单位:
ISOFLAVONE-RICH PASTA--CLINICAL AND COMMERCIAL POTENTIAL
-
批准号:2800102
-
项目类别:
-
资助金额:$56.03万
-
财政年份:1996
-
负责人:RICHARDUS ROSS
-
依托单位:
ISOFLAVONE RICH PASTA--CLINICAL AND COMMERCIAL POTENTIAL
-
批准号:2113849
-
项目类别:
-
资助金额:$9.81万
-
财政年份:1996
-
负责人:RICHARDUS ROSS
-
依托单位:
ROLE OF 1,25 DIHYDROXYVITAMIN D DURING FETAL LIFE
-
批准号:3157620
-
项目类别:
-
资助金额:$11.39万
-
财政年份:1986
-
负责人:RICHARDUS ROSS
-
依托单位:
THE ROLE OF 1,25 DIHYDROXYVITAMIN D DURING FETAL LIFE
-
批准号:3157621
-
项目类别:
-
资助金额:$11.04万
-
财政年份:1986
-
负责人:RICHARDUS ROSS
-
依托单位:
MATERNAL-FETAL MINERAL METABOLISM IN DIABETIC PREGNANCY
-
批准号:3842627
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:RICHARDUS ROSS
-
依托单位:
MATERNAL-FETAL MINERAL METABOLISM IN DIABETIC PREGNANCY
-
批准号:3756971
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:RICHARDUS ROSS
-
依托单位:
INDUCTION AND MAINTENANCE OF DIABETES IN THE PREGNANT SHEEP
-
批准号:3778861
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:RICHARDUS ROSS
-
依托单位:
INDUCTION AND MAINTENANCE OF DIABETES IN THE PREGNANT SHEEP
-
批准号:3857392
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:RICHARDUS ROSS
-
依托单位:
MATERNAL-FETAL MINERAL METABOLISM IN DIABETIC PREGNANCY
-
批准号:3878444
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:RICHARDUS ROSS
-
依托单位:
INDUCTION AND MAINTENANCE OF DIABETES IN THE PREGNANT SHEEP
-
批准号:3756965
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:RICHARDUS ROSS
-
依托单位:
MATERNAL-FETAL MINERAL METABOLISM IN DIABETIC PREGNANCY
-
批准号:3778867
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:RICHARDUS ROSS
-
依托单位:
MATERNAL-FETAL MINERAL METABOLISM IN DIABETIC PREGNANCY
-
批准号:3857398
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:RICHARDUS ROSS
-
依托单位:
INDUCTION AND MAINTENANCE OF DIABETES IN THE PREGNANT SHEEP
-
批准号:3842621
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:RICHARDUS ROSS
-
依托单位:
INDUCTION AND MAINTENANCE OF DIABETES IN THE PREGNANT SHEEP
-
批准号:3878438
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:RICHARDUS ROSS
-
依托单位:
海外基金