Development of immune function and avian gut health

免疫功能的发展和禽类肠道健康

• 批准号: BB/K004468/1
• 负责人: Adrian Smith
• 金额: $ 37.16万
• 依托单位: University of Oxford
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2013
• 资助国家: 英国
• 起止时间: 2013 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FK004468%2F1
• 关键词: Development; immune; function; avian; gut

Improving the health of animals reared for food is an essential element of sustainable farming and the DIFAGH programme is focussed on improving avian gut health. Poultry products (meat and eggs) represent the largest source of animal protein in the world and with increasing demand for efficient, sustainable supply with the highest ethical and ecological standards of farming. Prevention of disease is one of the most important factors in poultry welfare and sustainable production, especially since the majority of birds are young and immunologically immature (particularly in the gut). The DIFAGH project will directly impact on this area, focusing on the development of probiotic regimens that will improve the immune competence of young poultry and protect them against bacterial diseases. Improving immune competence will improve resistance of young birds to disease and improve the responses generated by vaccines. Improving gut health is a priority for the poultry industry since problems in the gut contribute significantly in other areas such as litter quality and the attendant issues related to hock burn and foot problems.The development of a strong consortium in the field of avian gut health will lead to a range of international exchange opportunities enriching the academic and cultural development of staff and students.The DIFAGH project represents a trans-European consortium involving experts in avian immunology, infectious disease, microflora analysis and probiotic development. We will employ state of the art approaches to identify and test for the effectiveness of probiotic formulations to improve the gut health of chickens. Importantly we will also seek formulations that reduce the capacity for infections to establish within the gut of poultry (including those with zoonotic capability).The benefits of our studies will positively impact on the welfare of many millions of poultry in the field. Furthermore, it will improve consumer protection by subsequently reducing the need for antimicrobial treatments, the prevalence of Campylobacter and Salmonella in poultry as well as reducing the incidence of disease in humans. All studies will be licensed by appropriate agencies and ethical review bodies with the highest standards of animal care.

改善食用动物的健康是可持续农业的一个基本要素，DIFAGH计划的重点是改善禽类肠道健康。家禽产品（肉类和蛋类）是世界上最大的动物蛋白来源，对高效、可持续供应的需求日益增长，并符合最高的农业道德和生态标准。预防疾病是家禽福利和可持续生产中最重要的因素之一，特别是因为大多数家禽都很年轻，免疫不成熟（特别是肠道）。DIFAGH项目将直接影响这一领域，重点是开发益生菌方案，提高幼禽的免疫能力，保护它们免受细菌性疾病的侵害。提高免疫能力将提高幼鸟对疾病的抵抗力，并提高疫苗产生的反应。改善肠道健康是家禽业的优先事项，因为肠道问题在其他领域有很大的影响，如垫料质量和与飞节烧伤和足部问题相关的问题。在禽肠道健康领域建立一个强大的联盟将带来一系列国际交流机会，丰富教职员工和学生的学术和文化发展。DIFAGH项目代表了一个跨学科的项目，由禽类免疫学、传染病、微生物区系分析和益生菌开发专家组成的欧洲联盟。我们将采用最先进的方法来鉴定和测试益生菌制剂改善鸡肠道健康的有效性。重要的是，我们还将寻求降低家禽肠道内感染能力的制剂（包括具有人畜共患病能力的家禽）。我们的研究成果将对该领域数百万家禽的福利产生积极影响。此外，它将通过随后减少对抗菌治疗的需求、弯曲杆菌和沙门氏菌在家禽中的流行以及减少人类疾病的发生率来改善消费者保护。所有研究都将由具有最高动物护理标准的适当机构和伦理审查机构许可。

项目成果

Early pathogenesis during infectious bursal disease in susceptible chickens is associated with changes in B cell genomic methylation and loss of genome integrity.

• DOI: 10.1016/j.dci.2017.03.014
• 发表时间: 2017-08
• 期刊: Developmental and comparative immunology
• 影响因子: 2.9
• 作者: Ciccone NA;Smith LP;Mwangi W;Boyd A;Broadbent AJ;Smith AL;Nair V
• 通讯作者: Nair V

Monitoring chicken flock behaviour provides early warning of infection by human pathogen Campylobacter.

• DOI: 10.1098/rspb.2015.2323
• 发表时间: 2016-01-13
• 期刊: Proceedings. Biological sciences
• 作者: Colles FM;Cain RJ;Nickson T;Smith AL;Roberts SJ;Maiden MC;Lunn D;Dawkins MS
• 通讯作者: Dawkins MS

High resolution parallel sequencing reveals multi-strain Campylobacter in broiler chicken flocks testing 'negative' by conventional culture methods: implications for control of Campylobacter infection

高分辨率并行测序揭示肉鸡群中的多菌株弯曲杆菌通过传统培养方法检测为“阴性”：对控制弯曲杆菌感染的影响

• DOI: 10.1101/2022.03.28.485779
• 发表时间: 2022
• 作者: Colles F

High resolution parallel sequencing reveals multistrain Campylobacter in broiler chicken flocks testing 'negative' by conventional culture methods: implications for control of Campylobacter infection.

• DOI: 10.1016/j.psj.2022.102048
• 发表时间: 2022-10
• 期刊: POULTRY SCIENCE
• 影响因子: 4.4
• 作者: Colles, Frances M.;Karasova, Daniela;Crhanova, Magdalena;Preston, Stephen G.;Smith, Adrian L.;Dawkins, Marian S.;Rychlik, Ivan;Gebhardt-Henrich, Sabine G.
• 通讯作者: Gebhardt-Henrich, Sabine G.