Identification of protective Chalmydia antigens using a novel technology

使用新技术鉴定保护性衣原体抗原

• 批准号: BB/J010855/1
• 负责人: Adrian Smith
• 金额: $ 19.95万
• 依托单位: University of Oxford
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2012
• 资助国家: 英国
• 起止时间: 2012 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FJ010855%2F1
• 关键词: Identification; protective; Chalmydia; antigens; using

BBSRC funded research led to the discovery of a unique approach to identify antigens that confer protective immunity. This approach, known as Protecta Antigen Finding (PAF) allows discrimination of pathogen-derived antigens that mediate protection from the larger cohort that simply stimulate a response. PAF has stimulated significant interest within the vaccine industry, Seed Fund and Venture Capital sectors. To realise the commercial potential of PAF we have demonstrated PAF utility in vaginal Chlamydia infection. The key objective of this FOF application is to perform the next phase of PAF and identify the antigens that afford protection. A panel of new protective antigens against Chlamydia will provide a foundation for commercial exploitation via spin-out and/or licensing routes. The PAF project has a solid IP platform and has attracted a small amount of seed funding and developed a robust commercial and technical plan necessary to succeed in this competitive and high impact arena.

BBSRC资助的研究导致发现了一种独特的方法来识别赋予保护性免疫力的抗原。这种方法称为保护抗原发现（PAF）允许区分病原体衍生的抗原，这些抗原介导了仅刺激反应的较大队列的保护。 PAF激发了疫苗行业，种子基金和风险投资部门的重大兴趣。为了实现PAF的商业潜力，我们在阴道衣原体感染中证明了PAF效用。该FOF应用程序的主要目的是执行PAF的下一阶段，并确定提供保护的抗原。针对衣原体的新保护抗原小组将通过拆卸和/或许可路线为商业剥削提供基础。 PAF项目具有坚实的IP平台，并吸引了少量的种子资金，并制定了在这个竞争激烈和高影响力领域取得成功所必需的商业和技术计划。

项目成果

Early pathogenesis during infectious bursal disease in susceptible chickens is associated with changes in B cell genomic methylation and loss of genome integrity.

• DOI: 10.1016/j.dci.2017.03.014
• 发表时间: 2017-08
• 期刊: Developmental and comparative immunology
• 影响因子: 2.9
• 作者: Ciccone NA;Smith LP;Mwangi W;Boyd A;Broadbent AJ;Smith AL;Nair V
• 通讯作者: Nair V

Host genetics determine susceptibility to avian influenza infection and transmission dynamics.

• DOI: 10.1038/srep26787
• 发表时间: 2016-06-09
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Ruiz-Hernandez R;Mwangi W;Peroval M;Sadeyen JR;Ascough S;Balkissoon D;Staines K;Boyd A;McCauley J;Smith A;Butter C
• 通讯作者: Butter C

Colonization pattern of C. jejuni isolates of human and avian origin and differences in the induction of immune responses in chicken.

人类和鸟类来源的空肠弯曲菌分离株的定植模式以及在鸡中诱导免疫反应的差异。

• DOI: 10.1016/j.vetimm.2015.11.005
• 发表时间: 2016
• 期刊: Veterinary immunology and immunopathology
• 影响因子: 1.8
• 作者: Pielsticker C

Transient and Prolonged Response of Chicken Cecum Mucosa to Colonization with Different Gut Microbiota.

• DOI: 10.1371/journal.pone.0163932
• 发表时间: 2016
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Volf J;Polansky O;Varmuzova K;Gerzova L;Sekelova Z;Faldynova M;Babak V;Medvecky M;Smith AL;Kaspers B;Velge P;Rychlik I
• 通讯作者: Rychlik I

Differences in host breed and diet influence colonization by Campylobacter jejuni and induction of local immune responses in chicken.

• DOI: 10.1186/s13099-016-0133-1
• 发表时间: 2016
• 期刊: Gut pathogens
• 影响因子: 4.2
• 作者: Han Z;Willer T;Pielsticker C;Gerzova L;Rychlik I;Rautenschlein S
• 通讯作者: Rautenschlein S