To benchmark the utility of E06: A half-life extension, single-domain, shark antibody bio-tool, and progress it to a Phase 1 ready candidate clone
To benchmark the utility of E06: A half-life extension, single-domain, shark antibody bio-tool, and progress it to a Phase 1 ready candidate clone
批准号:
BB/K010905/1
负责人:
Andrew Porter
金额:
$55.49万
依托单位:
依托单位国家:
英国
项目类别:
Research Grant
财政年份:
2013
资助国家:
英国
项目状态:
已结题
起止时间:
2013 至 --
中文摘要
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英文摘要
Scientifically we are developing a "bio-tool" that could be fused to a range of different therapeutic proteins/peptides to extend their serum half-life from hours to weeks, with the potential of greatly increasing their therapeutic potency. It works by hitching a ride on other long-lived proteins in the blood. Commercially, our medium-term goal is to create a Drug Discovery company, based on our unique, single-domain shark antibody (VNAR) platform, which will develop therapeutic agents in-house or in partnership with larger companies. To achieve this, meeting of scientific milestones is key, and in particular confirming non-immunogenicity (not seen by the human immune system & safe for use), and validate the most advanced of our products (E06 VNAR half-life extension bio-tool). Progress towards this goal will also provide a platform for NewCo formation and equity raising, and will deliver an asset capable of securing multiple revenue streams of licensing and partnered income.
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DOI:
10.3389/fimmu.2017.01361
发表时间:
2017
期刊:
Frontiers in immunology
影响因子:
7.3
作者:
[Steven J, Müller MR, Carvalho MF, Ubah OC, Kovaleva M, Donohoe G, Baddeley T, Cornock D, Saunders K, Porter AJ, Barelle CJ]
通讯作者:
Barelle CJ
In Vitro ELISA and Cell-Based Assays Confirm the Low Immunogenicity of VNAR Therapeutic Constructs in a Mouse Model of Human RA: An Encouraging Milestone to Further Clinical Drug Development.
体外 ELISA 和基于细胞的测定证实 VNAR 治疗结构在人类 RA 小鼠模型中的低免疫原性:进一步临床药物开发的一个令人鼓舞的里程碑。
DOI:
10.1155/2020/7283239
发表时间:
2020
期刊:
Journal of immunology research
影响因子:
4.1
作者:
[Ubah OC]
通讯作者:
Ubah OC
DOI:
10.4161/19420862.2015.989032
发表时间:
2015
期刊:
mAbs
影响因子:
5.3
作者:
[Zielonka S, Empting M, Grzeschik J, Könning D, Barelle CJ, Kolmar H]
通讯作者:
Kolmar H
DOI:
10.3389/fimmu.2017.01121
发表时间:
2017
期刊:
Frontiers in immunology
影响因子:
7.3
作者:
[Kovaleva M, Johnson K, Steven J, Barelle CJ, Porter A]
通讯作者:
Porter A
DOI:
10.1155/2018/4089459
发表时间:
2018
期刊:
Journal of immunology research
影响因子:
4.1
作者:
[O'Dwyer R, Kovaleva M, Zhang J, Steven J, Cummins E, Luxenberg D, Darmanin-Sheehan A, Carvalho MF, Whitters M, Saunders K, Barelle CJ]
通讯作者:
Barelle CJ
Cell cycle control of DNA double strand break repair and the role of Cdk
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批准号:BB/H003371/1
-
项目类别:Research Grant
-
资助金额:$40.35万
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财政年份:2010
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负责人:Andrew Porter
-
依托单位:
海外基金