NATURALLY-OCCURRING ANTICANCER PRINCIPLES

天然抗癌原理

• 批准号: 3165257
• 负责人: Geoffrey A Cordell
• 金额: $ 16.56万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 1979
• 资助国家: 美国
• 起止时间: 1979-04-01 至 1994-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3165257
• 关键词: X ray crystallography; antineoplastic antibiotics; antineoplastics; bioassay; chromatography; conformation; dosage; drug adverse effect; drug design /synthesis /production; drug metabolism; drug screening /evaluation; medicinal plants; neoplasm /cancer immunotherapy; nuclear magnetic resonance spectroscopy; pharmacology; plant extracts

The search for new and effective treatments for the group of diseases known collectively as cancer continues to be a highly significant research goal. In continuance of a highly productive research program aimed at the several aspects of the development of new potential anticancer agents a multidisciplinary program is proposed. The specific aims of the proposed research are: i) Daphnopsis sellowiana, Gelsemium elegans, Catharanthus roseus, and Camptotheca acuminata, ii) determination of the structure of the biologically active compounds isolated using both spectroscopic and chemical interconversion techniques, iii) structure modification and/or synthesis of new and selected known compounds with a view to establishing unambiguous spectroscopic properties, enhancing activity and/or understanding the mechanism of action of known antitumor agents (e.g. acronycine, fagaronine, modified camptothecine derivatives, the morphinandienone system, crinasiatine and secamine derivatives), iv) conformational analysis of selected biologically active compounds, v) biosynthesis of selected antitumor antibiotics (e.g. staurosporine); vi) evaluation of selected plants for antineoplastic activity and fractionation for their active principles; and vii) investigation of the dose relationship between immune stimulation and cytotoxic activity. All isolates and synthetic intermediates will typically be evaluated against a broad range of in vitro test systems.

为该组疾病寻找新的有效治疗方法 统称为癌症继续是一种非常重要的 研究目标。继续进行一项富有成效的研究计划 针对发展新潜力的几个方面 抗癌药物是一个多学科的项目。具体的 拟议研究的目的是：i)水仙、钩吻 、长春花属和喜树属，II) 生物活性化合物的结构测定 利用光谱和化学相互转化分离 技术，三)结构修饰和/或合成新的和 选定的已知化合物，以期建立明确的 光谱性质，增强活性和/或了解 已知的抗肿瘤药物的作用机制(例如， 阿加罗宁、喜树碱衍生物、吗啡二烯酮 体系，金雀花碱和塞克明衍生物)，四)构象 选定生物活性化合物的分析，v)生物合成 选定的抗肿瘤抗生素(例如星形孢菌素)；vi)评价 精选的抗肿瘤活性植物及其分级 有效原则；和vii)剂量关系的调查 免疫刺激和细胞毒活性之间的关系。所有分离株和 合成中间体通常会在广泛的范围内进行评估 体外测试系统。