NATURALLY-OCCURRING ANTICANCER PRINCIPLES

天然抗癌原理

• 批准号: 3165250
• 负责人: Geoffrey A Cordell
• 金额: $ 18.53万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 1979
• 资助国家: 美国
• 起止时间: 1979-04-01 至 1994-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3165250
• 关键词: antineoplastic antibiotics; antineoplastics; bioassay; chromatography; conformation; dosage; drug adverse effect; drug design /synthesis /production; drug metabolism; drug screening /evaluation; medicinal plants; neoplasm /cancer immunotherapy; nuclear magnetic resonance spectroscopy; pharmacology; plant extracts

The search for new and effective treatments for the group of diseases known collectively as cancer continues to be a highly significant research goal. In continuance of a highly productive research program aimed at the several aspects of the development of new potential anticancer agents a multidisciplinary program is proposed. The specific aims of the proposed research are: i) Daphnopsis sellowiana, Gelsemium elegans, Catharanthus roseus, and Camptotheca acuminata, ii) determination of the structure of the biologically active compounds isolated using both spectroscopic and chemical interconversion techniques, iii) structure modification and/or synthesis of new and selected known compounds with a view to establishing unambiguous spectroscopic properties, enhancing activity and/or understanding the mechanism of action of known antitumor agents (e.g. acronycine, fagaronine, modified camptothecine derivatives, the morphinandienone system, crinasiatine and secamine derivatives), iv) conformational analysis of selected biologically active compounds, v) biosynthesis of selected antitumor antibiotics (e.g. staurosporine); vi) evaluation of selected plants for antineoplastic activity and fractionation for their active principles; and vii) investigation of the dose relationship between immune stimulation and cytotoxic activity. All isolates and synthetic intermediates will typically be evaluated against a broad range of in vitro test systems.

寻找新的和有效的治疗方法， 被统称为癌症的癌症仍然是一个非常重要的 研究目标 为了继续进行一项高产的研究计划， 针对几个方面开发新的潜力 抗癌剂的多学科计划提出。 具体 本研究的目的是：i）川滇瑞香，钩吻 elegans，Catharanthus roseus和Camptotheca acuminata，ii） 生物活性化合物结构的测定 分离使用光谱和化学互变 技术，iii）结构修饰和/或合成新的和 选择已知化合物，以确定明确的 光谱特性，增强活性和/或理解 已知的抗肿瘤剂（例如，阿克柔霉素， 法加替尼，改性喜树碱衍生物，吗啡二烯酮 系统，crinasiatine和secamine衍生物），iv）构象 选择的生物活性化合物的分析，v） 选择的抗肿瘤抗生素（例如星形孢菌素）; vi）评价 选择植物的抗氧化活性和分馏， 活性成分;和vii）剂量关系的研究 免疫刺激和细胞毒活性之间的联系 所有分离株和 合成中间体通常将针对宽范围的 体外测试系统。