课题基金 / 基金详情

NATURALLY-OCCURRING ANTICANCER PRINCIPLES

NATURALLY-OCCURRING ANTICANCER PRINCIPLES
天然抗癌原理
批准号:
3165259
负责人:
Geoffrey A Cordell
金额:
$17.45万
依托单位国家:
美国
项目类别:
财政年份:
1979
资助国家:
美国
项目状态:
已结题
起止时间:
1979-04-01 至 1994-04-30

项目摘要

项目成果

Geoffrey A Cordell的其他基金

相关文献

中文摘要
翻译
寻找针对该组疾病的新的有效治疗方法 统称为癌症仍然是一个非常重要的 研究目标。 继续高效的研究计划 针对几个方面发展新潜力 提出了抗癌剂多学科计划。 具体的 拟议研究的目标是: i) Daphnopsis sellowiana、Gelsemium 线虫、长春花和喜树,ii) 生物活性化合物结构的测定 使用光谱和化学互变进行分离 技术,iii) 结构修饰和/或合成新的和 选择已知化合物,以明确确定 光谱特性,增强活性和/或理解 已知抗肿瘤药物的作用机制(例如 acronycine、 法加洛宁、改性喜树碱衍生物、吗啡二烯酮 系统,crinasiatine 和 secamine 衍生物),iv)构象 分析选定的生物活性化合物,v) 的生物合成 选定的抗肿瘤抗生素(例如星形孢菌素); vi) 评估 选择具有抗肿瘤活性的植物并对其进行分馏 积极原则; vii) 剂量关系的调查 免疫刺激和细胞毒活性之间的关系。 所有分离株和 合成中间体通常会根据广泛的范围进行评估 体外测试系统。
英文摘要
The search for new and effective treatments for the group of diseases known collectively as cancer continues to be a highly significant research goal. In continuance of a highly productive research program aimed at the several aspects of the development of new potential anticancer agents a multidisciplinary program is proposed. The specific aims of the proposed research are: i) Daphnopsis sellowiana, Gelsemium elegans, Catharanthus roseus, and Camptotheca acuminata, ii) determination of the structure of the biologically active compounds isolated using both spectroscopic and chemical interconversion techniques, iii) structure modification and/or synthesis of new and selected known compounds with a view to establishing unambiguous spectroscopic properties, enhancing activity and/or understanding the mechanism of action of known antitumor agents (e.g. acronycine, fagaronine, modified camptothecine derivatives, the morphinandienone system, crinasiatine and secamine derivatives), iv) conformational analysis of selected biologically active compounds, v) biosynthesis of selected antitumor antibiotics (e.g. staurosporine); vi) evaluation of selected plants for antineoplastic activity and fractionation for their active principles; and vii) investigation of the dose relationship between immune stimulation and cytotoxic activity. All isolates and synthetic intermediates will typically be evaluated against a broad range of in vitro test systems.
期刊论文(42)
专著(0)
科研奖励(0)
会议论文
Biosynthesis of staurosporine, 2. Incorporation of tryptophan.
星形孢菌素的生物合成,2.色氨酸的掺入。
DOI: 10.1021/np50059a013
发表时间: 1988
期刊: Journal of natural products
影响因子: 5.1
作者: [Meksuriyen,D, Cordell,GA]
通讯作者: Cordell,GA
Bisamides from Aglaia species: structure analysis and potential to reverse drug resistance with cultured cells.
来自米香属物种的双酰胺:结构分析和逆转培养细胞耐药性的潜力。
DOI: 10.1021/np50094a004
发表时间: 1993
期刊: Journal of natural products
影响因子: 5.1
作者: [Saifah,E, Puripattanavong,J, Likhitwitayawuid,K, Cordell,GA, Chai,H, Pezzuto,JM]
通讯作者: Pezzuto,JM
DOI: 10.1021/np50042a009
发表时间: 1985
期刊: Journal of natural products
影响因子: 5.1
作者: [Funayama,S, Cordell,GA]
通讯作者: Cordell,GA
Enkleine: an isoquinolone from Enkleia siamensis.
Enkleine:来自 Enkleia siamensis 的异喹诺酮。
DOI: 10.1055/s-2006-960214
发表时间: 1991
期刊: Planta medica
影响因子: 2.7
作者: [Boonyaratanakornkit,L, Che,CT, Cordell,GA, Fong,HH, Farnsworth,NR]
通讯作者: Farnsworth,NR
22
    NOVEL STRATEGIES FOR PLANT-DERIVED ANTICANCER AGENTS
    • 批准号:
      3549682
    • 项目类别:
    • 资助金额:
      $85.28万
    • 财政年份:
      1990
    • 负责人:
      Geoffrey A Cordell
    • 依托单位:
    BIOMEDICAL RESEARCH SUPPORT
    • 批准号:
      3518669
    • 项目类别:
    • 资助金额:
      $9.23万
    • 财政年份:
      1987
    • 负责人:
      Geoffrey A Cordell
    • 依托单位:
    INSTRUMENTATION AT UNIVERSITY OF ILLINOIS-CHICAGO
    • 批准号:
      3524623
    • 项目类别:
    • 资助金额:
      $2.82万
    • 财政年份:
      1987
    • 负责人:
      Geoffrey A Cordell
    • 依托单位:
    MINORITY HIGH SCHOOL STUDENT RESEARCH APPRENTICE PROGRAM
    • 批准号:
      3510299
    • 项目类别:
    • 资助金额:
      $0.6万
    • 财政年份:
      1985
    • 负责人:
      Geoffrey A Cordell
    • 依托单位: