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NATURALLY-OCCURRING ANTICANCER PRINCIPLES

天然抗癌原理

基本信息

批准号：
3165259
负责人：
Geoffrey A Cordell
金额：
$ 17.45万
依托单位：
UNIVERSITY OF ILLINOIS AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
1979
资助国家：
美国
起止时间：
1979-04-01 至 1994-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/3165259
关键词：
X ray crystallography antineoplastic antibiotics antineoplastics bioassay chromatography conformation dosage drug adverse effect drug design /synthesis /production drug metabolism drug screening /evaluation medicinal plants neoplasm /cancer immunotherapy nuclear magnetic resonance spectroscopy pharmacology plant extracts vinca alkaloids

项目摘要

The search for new and effective treatments for the group of diseases known collectively as cancer continues to be a highly significant research goal. In continuance of a highly productive research program aimed at the several aspects of the development of new potential anticancer agents a multidisciplinary program is proposed. The specific aims of the proposed research are: i) Daphnopsis sellowiana, Gelsemium elegans, Catharanthus roseus, and Camptotheca acuminata, ii) determination of the structure of the biologically active compounds isolated using both spectroscopic and chemical interconversion techniques, iii) structure modification and/or synthesis of new and selected known compounds with a view to establishing unambiguous spectroscopic properties, enhancing activity and/or understanding the mechanism of action of known antitumor agents (e.g. acronycine, fagaronine, modified camptothecine derivatives, the morphinandienone system, crinasiatine and secamine derivatives), iv) conformational analysis of selected biologically active compounds, v) biosynthesis of selected antitumor antibiotics (e.g. staurosporine); vi) evaluation of selected plants for antineoplastic activity and fractionation for their active principles; and vii) investigation of the dose relationship between immune stimulation and cytotoxic activity. All isolates and synthetic intermediates will typically be evaluated against a broad range of in vitro test systems.

寻找新的和有效的治疗方法，被统称为癌症的癌症仍然是一个非常重要的研究目标为了继续进行一项高产的研究计划，针对几个方面开发新的潜力抗癌剂的多学科计划提出。具体本研究的目的是：i）川滇瑞香，钩吻 elegans，Catharanthus roseus和Camptotheca acuminata，ii）生物活性化合物结构的测定分离使用光谱和化学互变技术，iii）结构修饰和/或合成新的和选择已知化合物，以确定明确的光谱特性，增强活性和/或理解已知的抗肿瘤剂（例如，阿克柔霉素，法加宁、修饰的喜树碱衍生物、吗啡二酮系统，crinasiatine和secamine衍生物），iv）构象选择的生物活性化合物的分析，v）选择的抗肿瘤抗生素（例如星形孢菌素）; vi）评价选择植物的抗氧化活性和分馏，活性成分;和vii）剂量关系的研究免疫刺激和细胞毒活性之间的联系所有分离株和合成中间体通常将针对宽范围的体外测试系统。