NATURALLY-OCCURRING ANTICANCER PRINCIPLES

寻找针对该组疾病的新的有效治疗方法 统称为癌症仍然是一个非常重要的 研究目标。 继续高效的研究计划 针对几个方面发展新潜力 提出了抗癌剂多学科计划。 具体的 拟议研究的目标是： i) Daphnopsis sellowiana、Gelsemium 线虫、长春花和喜树，ii) 生物活性化合物结构的测定 使用光谱和化学互变进行分离 技术，iii) 结构修饰和/或合成新的和 选择已知化合物，以明确确定 光谱特性，增强活性和/或理解 已知抗肿瘤药物的作用机制（例如 acronycine、 法加洛宁、改性喜树碱衍生物、吗啡二烯酮 系统，crinasiatine 和 secamine 衍生物），iv）构象 分析选定的生物活性化合物，v) 的生物合成 选定的抗肿瘤抗生素（例如星形孢菌素）； vi) 评估 选择具有抗肿瘤活性的植物并对其进行分馏 积极原则； vii) 剂量关系的调查 免疫刺激和细胞毒活性之间的关系。 所有分离株和 合成中间体通常会根据广泛的范围进行评估 体外测试系统。

The search for new and effective treatments for the group of diseases known collectively as cancer continues to be a highly significant research goal. In continuance of a highly productive research program aimed at the several aspects of the development of new potential anticancer agents a multidisciplinary program is proposed. The specific aims of the proposed research are: i) Daphnopsis sellowiana, Gelsemium elegans, Catharanthus roseus, and Camptotheca acuminata, ii) determination of the structure of the biologically active compounds isolated using both spectroscopic and chemical interconversion techniques, iii) structure modification and/or synthesis of new and selected known compounds with a view to establishing unambiguous spectroscopic properties, enhancing activity and/or understanding the mechanism of action of known antitumor agents (e.g. acronycine, fagaronine, modified camptothecine derivatives, the morphinandienone system, crinasiatine and secamine derivatives), iv) conformational analysis of selected biologically active compounds, v) biosynthesis of selected antitumor antibiotics (e.g. staurosporine); vi) evaluation of selected plants for antineoplastic activity and fractionation for their active principles; and vii) investigation of the dose relationship between immune stimulation and cytotoxic activity. All isolates and synthetic intermediates will typically be evaluated against a broad range of in vitro test systems.