MODULATION OF THE ANTITUMOR EFFECT OF INTERFERON
MODULATION OF THE ANTITUMOR EFFECT OF INTERFERON
批准号:
3167328
负责人:
WILLIAM R FLEISCHMANN
金额:
$17.35万
依托单位国家:
美国
项目类别:
财政年份:
1983
资助国家:
美国
项目状态:
已结题
起止时间:
1983-12-01 至 1989-11-30
关键词:
antineoplastics antiviral agents cell growth regulation clone cells colony stimulating factor combination cancer therapy cyclic AMP cyclic GMP human therapy evaluation immunological substance immunoregulation interferon inducers interferons laboratory mouse lymphokines molecular oncology neoplasm /cancer chemotherapy neoplasm /cancer immunotherapy spleen
中文摘要
干扰素(干扰素-α、干扰素-β和干扰素-γ)是天然的
宿主蛋白具有抗病毒、免疫调节和
抗增殖活性。一些临床试验已经
检查干扰素的临床潜力。不幸的是,
虽然他们表现出了真正的希望来控制某些
癌症的类型,它们的有效性和
尚未发现对大多数类型的病毒有很强的抵抗力
检测出的癌症。此外,干扰素疗法有许多
副作用,包括骨髓抑制。一位少校
挑战是增加干扰素的抗肿瘤活性
同时减少或减轻它们的副作用。这项建议
通过1)评估联合干扰素来关注这一挑战
治疗(干扰素-γ加干扰素-α或干扰素-β)
作为最大化干扰素的手段的各种治疗方案
活性;2)评价菌落刺激的综合效果
因子和其他骨髓调节剂作为一种手段
尽量减少干扰素的骨髓抑制作用
治疗;3)从干扰素中去除干扰素作用的抑制物-
作为使干扰素-γ最大化的手段的伽马制剂
活性;以及,4)评估抗肿瘤的联合作用
药物和干扰素作为最大化其抗肿瘤作用的手段
活动。这项拟议的研究旨在调查基本的
机制,同时为临床提供重要的见解
干扰素的应用。
英文摘要
Interferons (IFN-alpha, IFN-beta, and IFN-gamma) are natural
host proteins which have antiviral, immunoregulatory, and
antiproliferative activities. A number of clinical trials have
examined interferons for their clinical potential. Unfortunately,
while they have shown real promise for the control of certain
types of cancer, they have been limited in their effectiveness and
have not been found to be highly potent against most of the types
of cancers tested. Further, interferon therapy has a number of
side effects, including bone marrow suppression. A major
challenge is to increase the antitumor activity of the interferons
while reducing or moderating their side effects. This proposal
focuses on this challenge by 1) evaluating combined interferon
treatment (IFN-gamma plus either IFN-alpha or IFN-beta) in
various treatment protocols as a means of maximizing interferon
activity; 2) evaluating the combined effects of colony stimulating
factors and other myeloregulatory agents as a means of
minimizing the bone marrow suppressive effect of interferon
therapy; 3) removing an inhibitor of interferon action from IFN-
gamma preparations as a means of maximizing IFN-gamma
activity; and, 4) evaluating the combined effects of antitumor
drugs and interferons as a means of maximizing their antitumor
activities. The proposed research seeks to investigate basic
mechanisms, while providing important insights for the clinical
application of interferon.
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会议论文
CHRONOBIOLOGY OF INTERFERON THERAPY
-
批准号:2093968
-
项目类别:
-
资助金额:$28.01万
-
财政年份:1990
-
负责人:WILLIAM R FLEISCHMANN
-
依托单位:
CHRONOBIOLOGY OF INTERFERON THERAPY
-
批准号:3195414
-
项目类别:
-
资助金额:$22.58万
-
财政年份:1990
-
负责人:WILLIAM R FLEISCHMANN
-
依托单位:
CHRONOBIOLOGY OF INTERFERON THERAPY
-
批准号:3195415
-
项目类别:
-
资助金额:$25.87万
-
财政年份:1990
-
负责人:WILLIAM R FLEISCHMANN
-
依托单位:
CHRONOBIOLOGY OF INTERFERON THERAPY
-
批准号:3195413
-
项目类别:
-
资助金额:$20.99万
-
财政年份:1990
-
负责人:WILLIAM R FLEISCHMANN
-
依托单位:
CHRONOBIOLOGY OF INTERFERON THERAPY
-
批准号:3195416
-
项目类别:
-
资助金额:$27.49万
-
财政年份:1990
-
负责人:WILLIAM R FLEISCHMANN
-
依托单位:
MODULATION OF THE ANTITUMOR EFFECT OF INTERFERON
-
批准号:3167323
-
项目类别:
-
资助金额:$17.32万
-
财政年份:1983
-
负责人:WILLIAM R FLEISCHMANN
-
依托单位:
MODULATION OF THE ANTITUMOR EFFECT OF INTERFERON
-
批准号:3167326
-
项目类别:
-
资助金额:$14.01万
-
财政年份:1983
-
负责人:WILLIAM R FLEISCHMANN
-
依托单位:
MODULATION OF THE ANTITUMOR EFFECT OF INTERFERON
-
批准号:3167329
-
项目类别:
-
资助金额:$16.86万
-
财政年份:1983
-
负责人:WILLIAM R FLEISCHMANN
-
依托单位:
MODULATION OF THE ANTITUMOR EFFECT OF INTERFERON
-
批准号:3167327
-
项目类别:
-
资助金额:$14.75万
-
财政年份:1983
-
负责人:WILLIAM R FLEISCHMANN
-
依托单位:
海外基金