GENETIC EPIDEMIOLOGY OF CANCER IN UTAH GENEALOGIES

这项研究试图了解癌症的根本原因在一个明确的 遗传和环境因素将同时存在的种群 检查过了。130万犹他州摩门教徒和 犹他州癌症登记处的记录为分析 癌症发生在亲属身上。这个群体是稳定的，合作的， 在基因上与其他起源于北欧的种群相似。 继续发展和完善内部记录的链接 家谱以及家谱、癌症登记和死亡之间的关系 证书对于人口使用这些资源是必不可少的 基于分析。这项研究的另一个目标是改善 用于访问和分析记录的数据库系统。 患有癌症的亲属集群将从家谱和 辅助记录。所有有三个或三个以上亲属的癌症集群 在同一地点受影响的癌症类型将被检查 一起发生。一些家谱，其中有大量相关的人 都被发现患有癌症，将被检查一种基因之间的联系 导致癌症和细胞癌基因。如果与癌基因的紧密连锁是 不包括在内，将执行一般关联研究，该研究将分析 遗传模型和基因外显性。在以下地点发生癌症的个案 家庭将与那些没有家族史的家庭进行比较，以及 已知与癌症相关的环境因素将被比较。 在分析过程中，谱系分析的工具，发生了 亲属中的疾病，以及大型人口数据库的测量 将继续发展。 这一结果将使人们能够评估基因在导致 以及一个研究其他疾病的模型，这些疾病由遗传和 环境因素。

This research seeks to understand fundamental causes of cancer in a defined population in which both genetic and environmental factors will be examined. The computerized genealogy of the 1.3 million Utah Mormons and the records of the Utah Cancer Registry provide the basis for analysis of cancer occurrence in relatives. This population is stable, cooperative, and genetically similar to other populations of Northern European origin. The continued development and refinement of the linking of records within the genealogy and between the genealogy, cancer registry and death certificates is essential for the use of these resources for population based analysis. Another goal of the research is the improvement of the database system for access to and analysis of records. Clusters of relatives with cancer will be identified from the genealogy and auxiliary records. All cancer clusters with three or more relatives affected at the same site will be examined for the types of cancers which occur together. Some pedigrees, in which a large number of related people are found to have had cancer, will be examined for linkage between a gene causing cancer and cellular oncogenes. If tight linkage to oncogenes is excluded, a general linkage study will be performed which will analyze genetic models and gene penetrance. Cases of cancer occurring within families will be compared to those with no family history, and environmental factors known to be associated with cancer will be compared. In the process of analysis, the tools for analysis of pedigrees, occurrence of diseases in relatives, and measurement of the large population database will continue to be developed. The results will allow an assessment of the importance of genes in causing and a model for the study of other diseases caused by both genetic and environmental factos.