GENETIC EPIDEMIOLOGY OF CANCER IN UTAH GENEALOGIES

这项研究旨在了解癌症的基本原因，在一个定义的 遗传因素和环境因素都将被 考察 130万犹他州摩门教徒的计算机化家谱， 犹他州癌症登记处的记录为以下分析提供了基础： 亲属发生癌症。 这个种群稳定，合作 并且在遗传上与其他北方欧洲起源的种群相似。 继续发展和完善内部记录的链接 家谱和家谱之间，癌症登记和死亡 证书对于使用这些人口资源至关重要 基于分析。 研究的另一个目标是改善 用于访问和分析记录的数据库系统。 癌症亲属的集群将从家谱中确定， 辅助记录 所有癌症集群有三个或更多的亲属 受影响的同一部位将检查癌症类型， 一起发生。 一些系谱，其中有大量的相关的人 被发现患有癌症的人，将被检查是否有一个基因 导致癌症和细胞癌基因。 如果与癌基因的紧密联系 排除，将进行一般连锁研究，分析 遗传模型和基因多态性。 癌症发生在 将家庭与没有家族史的家庭进行比较， 将比较已知与癌症相关的环境因素。 在分析的过程中，分析谱系、发生情况的工具 亲属疾病和大型人口数据库的计量 将继续发展。 这些结果将有助于评估基因在导致癌症中的重要性。 以及研究由遗传和遗传引起的其他疾病的模型 环境因素。

This research seeks to understand fundamental causes of cancer in a defined population in which both genetic and environmental factors will be examined. The computerized genealogy of the 1.3 million Utah Mormons and the records of the Utah Cancer Registry provide the basis for analysis of cancer occurrence in relatives. This population is stable, cooperative, and genetically similar to other populations of Northern European origin. The continued development and refinement of the linking of records within the genealogy and between the genealogy, cancer registry and death certificates is essential for the use of these resources for population based analysis. Another goal of the research is the improvement of the database system for access to and analysis of records. Clusters of relatives with cancer will be identified from the genealogy and auxiliary records. All cancer clusters with three or more relatives affected at the same site will be examined for the types of cancers which occur together. Some pedigrees, in which a large number of related people are found to have had cancer, will be examined for linkage between a gene causing cancer and cellular oncogenes. If tight linkage to oncogenes is excluded, a general linkage study will be performed which will analyze genetic models and gene penetrance. Cases of cancer occurring within families will be compared to those with no family history, and environmental factors known to be associated with cancer will be compared. In the process of analysis, the tools for analysis of pedigrees, occurrence of diseases in relatives, and measurement of the large population database will continue to be developed. The results will allow an assessment of the importance of genes in causing and a model for the study of other diseases caused by both genetic and environmental factos.