EFFECTS OF LOW ENERGY ELECTRONS FROM AUGER PROCESSES

螺旋钻过程中低能电子的影响

• 批准号: 3170760
• 负责人: DANDAMUDI V RAO
• 金额: $ 16.73万
• 依托单位: UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 1982
• 资助国家: 美国
• 起止时间: 1982-05-01 至 1993-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3170760
• 关键词: autoradiography; cis platinum compound; laboratory mouse; radiation dosage; radiation hazard; radiation sensitivity; radiobiology; radionuclide imaging /scanning; spermatogenesis

Several radionuclides decaying by electron capture (EC) and internal conversion (IC) are widely used for imaging in Nuclear Medicine. Such radionuclides also emit numerous low and very low energy Auger electrons, and may cause extensive damage in biological systems, similar to the case of 125I. It is proposed to study the radiotoxicity of several commonly used radionuclides in vivo in experimental mice. Spermatogenesis will be used as a model to observe any excessive damage caused by the low energy electrons from the incorporated radionuclides. Comparison with the effects of beta-decaying radionuclides of the same element give the relative biological effectiveness (RBE) of the incorporated EC and IC radionuclides. Such information may be useful to estimate better a realistic radiation dose to the germ cells in the gonads of the patient from the clinical procedures. The observed RBE values may be considerably higher than l if highly localized energy deposition by the low energy electrons plays an important role. Completed studies give RBE of about 3.5 for 20lT lambda relative to 204T lambda. To understand the RBE values, autoradiographic and other studies will be conducted to determine the distribution of the radionuclides; theoretical Auger and Coster-Kronig electron spectra will be calculated; and appropriate dosimetric models will be developed. The low energy Auger electrons also offer new possibilities not yet explored. Using radiolabeled DNA-seeking chemotherapeutic agents such as cis-platimum, it is proposed to investigate in mouse tumor models possible enhancement of therapeutic efficacy with reduced chemotoxicity of the drug.

几种通过电子捕获（EC）和内部衰变的放射性核素

项目成果

Cytotoxicity of some indium radiopharmaceuticals in mouse testes.

一些铟放射性药物对小鼠睾丸的细胞毒性。

• 发表时间: 1988
• 期刊: Journal of nuclear medicine : official publication, Society of Nuclear Medicine
• 作者: Rao,DV;Sastry,KS;Grimmond,HE;Howell,RW;Govelitz,GF;Lanka,VK;Mylavarapu,VB
• 通讯作者: Mylavarapu,VB

Relative biological effectiveness of 99mTc radiopharmaceuticals.

99mTc 放射性药物的相对生物有效性。

• DOI: 10.1118/1.597230
• 发表时间: 1994
• 期刊: Medical physics
• 影响因子: 3.8
• 作者: Narra,VR;Sastry,KS;Goddu,SM;Howell,RW;Strand,SE;Rao,DV
• 通讯作者: Rao,DV

Considerations in the selection of radiopharmaceuticals for palliation of bone pain from metastatic osseous lesions.

选择放射性药物缓解转移性骨病变骨痛的考虑因素。

• 发表时间: 2000
• 期刊: Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
• 作者: Bouchet,LG;Bolch,WE;Goddu,SM;Howell,RW;Rao,DV
• 通讯作者: Rao,DV

Biological damage caused by Auger cascades.

俄歇级联造成的生物损害。

• DOI: 10.1016/s0140-6736(86)90970-0
• 发表时间: 1986
• 期刊: Lancet (London, England)
• 作者: Sastry,KS;Rao,DV
• 通讯作者: Rao,DV

Effects of diatrizoate and iopamidol on spermatogenesis.

泛影酸盐和碘帕醇对精子发生的影响。

• DOI: 10.1097/00004424-199312000-00016
• 发表时间: 1993
• 期刊: Investigative radiology
• 影响因子: 6.7
• 作者: Yaghmai,V;Harapanhalli,RS;Patel,YD;Baker,SR;Rao,DV
• 通讯作者: Rao,DV