CANCER INCIDENCE AND PHENOXY HERBICIDE EXPOSURE

拟议项目的总体目标是研究 在癌症发病率和接触苯氧基除草剂（2，4-D，2，4， 5-T和Silvex）。 推定的 致癌物，TCDD偶尔在2，4，5-T和Silvex中发现，但在 2，4-D。因此，暴露于2，4-D和所有苯氧基除草剂本身 将尽可能单独评估。 软组织肉瘤和 非何杰金氏淋巴瘤将是感兴趣的部位。 本研究将 在华盛顿州西部的13个县内进行，其中 苯氧基除草剂在林业管理、路边和 路权刷控制，和公共土地维护计划， 发生在1950年至1979年之间， 可提供居住人口。 拟议的程序需要 病例对照流行病学研究，包括（1）邮件调查和个人 采访技巧，以获得准确和完整的记录苯氧基 1950-1979年研究区13个县的除草剂使用情况;（2） 利用电脑绘图技术在地图上显示除草剂的使用范围 研究区域的地理坐标和环境 最感兴趣的时间段的强度，（3）使用基于人口的 肿瘤登记，以确定癌症病例，和随机抽样程序， 确定控制措施，以及（4）对所有员工进行面对面访谈， 获取有关接触历史和潜在风险的详细信息 混杂因素。 标准统计程序将用于 测量病例中苯氧基除草剂暴露的相对程度， 控制，从而估计特定部位癌症的相对风险 感兴趣 拟议的研究将评估癌症发病率， 与苯氧基除草剂接触的住宅和其他来源有关， 因此，将增加对长期健康影响的理解 这些化学品。 拟议研究所收集的数据将 包括关于苯氧基暴露的历史记录 为继续评价人口的状况提供基础 苯氧基/TCDD对癌症和其他长期健康影响 exposure.

The overall objective of the proposed project is to study the relationship between cancer incidence and exposure to phenoxy herbicides (2, 4-D, 2, 4, 5-T and Silvex) from environmental and occupational sources. The putative carcinogen, TCDD is occasionally found in 2, 4, 5-T and Silvex, but not in 2, 4-D. Hence, exposures to 2, 4-D and to all phenoxy herbicides per se will be separately evaluated where possible. Soft tissue sarcomas and non-Hodgkin's lymphomas will be the sites of interest. The study will be conducted within the 13 counties of western Washington State, wherein extensive usage of phenoxy herbicides for forestry management, roadside and right-of-way brush control, and public lands maintenance programs has occurred between 1950-1979, and for which concise cancer incidence data for the residential population are available. The proposed procedures entail a case-control epidemiologic study involving (1) mail survey and personal interview techniques to acquire an accurate and complete record of phenoxy herbicide use in the 13 county study area from 1950-1979, (2) the use of computer graphics techniques to display herbicide application areas on maps of the study area in terms of geographic coordinates and environmental intensities for time periods of intesest, (3) the use of a population-based tumor registry to identify cancer cases, and random sampling procedures to identify controls, and (4) face-to-face interviews of all sulbjects to acquire detailed information on exposure histories and potential confounding factors. Standard statistical procedures will be used to measure the relative extent of phenoxy herbicide exposure among cases and controls, and hence, to estimate relative risks of cancer of specific sites of interest. The proposed studies will evaluate cancer incidence in relation to residential and other sources of phenoxy herbicide exposure, and, hence, will increase the understanding of the long term health effects of these chemicals. The data to be collected in the proposed studies will comprise a historical record with respect to phenoxy exposure in the resident population, providing a basis for the continuing evaluation of cancer and other long term health effects in relation to phenoxy/TCDD exposure.