CUKPGP: Streptococcus suis in the pig meat supply chain: from genomics to control strategies.

CUKPGP：猪肉供应链中的猪链球菌：从基因组学到控制策略。

• 批准号: BB/L003902/1
• 负责人: Alexander Tucker
• 金额: $ 20.01万
• 依托单位: University of Cambridge
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2013
• 资助国家: 英国
• 起止时间: 2013 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FL003902%2F1
• 关键词: CUKPGP; Streptococcus; suis; pig; meat

Streptococcus suis (SS) is an important zoonotic pathogen of pigs with global relevance to pig productivity and human health. Strategies for SS control are needed to protect human health andto reduce dependence of pig production on antimicrobials. This project aims to identify control points for the prevention of SS related disease in pigs and humans. Longitudinal studies in UK and Chinese farms and abattoirs (intensive and traditional systems), with whole genome sequencing of isolates, will provide guidance to new control points for disease prevention by shedding light on strain diversity, fitness, and antimicrobial resistance along the supply chain. Sequences will be compared to those obtained from pig meat products and those available from human isolates. Risk factors for carriage of SS on consumer-ready pig-meat will be investigated. We will identify avenues for environmental control of SS using transposon directed insertion site sequencing (TraDIS) to explore the genes that underpin environmental survival of SS in the farm, abattoir and meat product context.All partners (Cambridge University, Huazhong Agricultural University (HAU), and Wellcome Trust Sanger Institute (WTSI)) have strong track records in SS research. CU and HAU hold a China Partnering Award, and all 3 work together within the existing BBSRC Longer and Larger funded consortium, 'A single platform diagnostic and multivalent vaccine approach to bacterial respiratory diseases of pigs'.

猪链球菌（Streptococcus suis，SS）是一种重要的人畜共患病病原，对猪的生产和人类健康具有重要影响。SS控制策略是保护人类健康和减少养猪生产对抗生素依赖的必要措施。该项目旨在确定预防猪和人类SS相关疾病的控制点。在英国和中国的农场和屠宰场（集约化和传统系统）进行的纵向研究，以及分离株的全基因组测序，将通过揭示供应链沿着的菌株多样性，适应性和抗菌素耐药性，为疾病预防的新控制点提供指导。将序列与从猪肉产品中获得的序列和从人分离株中获得的序列进行比较。本研究将探讨即食猪肉携带悬浮固体的风险因素。我们将通过转座子定向插入位点测序（TraDIS）来探索SS在农场、屠宰场和肉制品环境中生存的基因，以确定SS的环境控制途径。所有合作伙伴（剑桥大学、华中农业大学（HAU）和威康信托桑格研究所（WTSI））在SS研究方面都有良好的记录。CU和HAU获得了中国合作奖，这三家公司都在现有的BBSRC Longer和Larger资助的财团内合作，“猪细菌性呼吸道疾病的单一平台诊断和多价疫苗方法”。

项目成果

Large-scale genomic analysis of antimicrobial resistance in the zoonotic pathogen Streptococcus suis.

• DOI: 10.1186/s12915-021-01094-1
• 发表时间: 2021-09-07
• 期刊: BMC biology
• 影响因子: 5.4
• 作者: Hadjirin NF;Miller EL;Murray GGR;Yen PLK;Phuc HD;Wileman TM;Hernandez-Garcia J;Williamson SM;Parkhill J;Maskell DJ;Zhou R;Fittipaldi N;Gottschalk M;Tucker AWD;Hoa NT;Welch JJ;Weinert LA
• 通讯作者: Weinert LA

Genomic signatures of human and animal disease in the zoonotic pathogen Streptococcus suis.

• DOI: 10.1038/ncomms7740
• 发表时间: 2015-03-31
• 期刊: NATURE COMMUNICATIONS
• 影响因子: 16.6
• 作者: Weinert, Lucy A.;Chaudhuri, Roy R.;Wang, Jinhong;Peters, Sarah E.;Corander, Jukka;Jombart, Thibaut;Baig, Abiyad;Howell, Kate J.;Vehkala, Minna;Valimaki, Niko;Harris, David;Tran Thi Bich Chieu;Nguyen Van Vinh Chau;Campbell, James;Schultsz, Constance;Parkhill, Julian;Bentley, Stephen D.;Langford, Paul R.;Rycroft, Andrew N.;Wren, Brendan W.;Farrar, Jeremy;Baker, Stephen;Ngo Thi Hoa;Holden, Matthew T. G.;Tucker, Alexander W.;Maskell, Duncan J.
• 通讯作者: Maskell, Duncan J.

Additional file 2 of Large-scale genomic analysis of antimicrobial resistance in the zoonotic pathogen Streptococcus suis

人畜共患病原体猪链球菌抗生素耐药性大规模基因组分析的附加文件 2

• DOI: 10.6084/m9.figshare.16584368
• 发表时间: 2021
• 作者: Hadjirin N

Patterns of antimicrobial resistance in Streptococcus suis isolates from pigs with or without streptococcal disease in England between 2009 and 2014.

• DOI: 10.1016/j.vetmic.2017.06.002
• 发表时间: 2017-08
• 期刊: Veterinary microbiology
• 影响因子: 3.3
• 作者: Hernandez-Garcia J;Wang J;Restif O;Holmes MA;Mather AE;Weinert LA;Wileman TM;Thomson JR;Langford PR;Wren BW;Rycroft A;Maskell DJ;Tucker AW;BRADP1T Consortium
• 通讯作者: BRADP1T Consortium

Whole genome investigation of a divergent clade of the pathogen Streptococcus suis.

病原体链球菌链球菌发散进化枝的整个基因组研究。

• DOI: 10.3389/fmicb.2015.01191
• 发表时间: 2015
• 期刊: Frontiers in microbiology
• 影响因子: 5.2
• 作者: Baig A;Weinert LA;Peters SE;Howell KJ;Chaudhuri RR;Wang J;Holden MT;Parkhill J;Langford PR;Rycroft AN;Wren BW;Tucker AW;Maskell DJ
• 通讯作者: Maskell DJ