MECHANISM OF IMMUNE INTERFERON SYNTHESIS IN THYMOCYTES

胸腺细胞中免疫干扰素合成机制

• 批准号: 3171463
• 负责人: GABRIELLE H REEM
• 金额: $ 12.37万
• 依托单位: NEW YORK UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1983
• 资助国家: 美国
• 起止时间: 1983-08-01 至 1987-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3171463
• 关键词: B lymphocyte; T lymphocyte; cell differentiation; histocompatibility antigens; human tissue; immunoregulation; interferons; interleukin 2; monoclonal antibody; tissue /cell culture

This research has as its goal the study of the mechanism of induction of gamma interferon synthesis by human thymocytes in vitro. It is based on our original observation that human thymocytes can be induced to synthesize interferon by two agents: a lectin and products of B-lymphoblastoid cell lines. This is the first observation of induction of gamma interferon, a lymphokine, by precursors of T lymphocytes. It is our aim to identify the thymocyte subsets that are induced and to correlate the induction of interferon synthesis with the acquisition of other immune functions characteristic of mature T lymphocytes. T lymphocytes play a crucial role in cellular immune defense, and the recruitment of thymocytes in immune defense against pathogens or tumor cells may be of vital importance. In view of the response of thymocytes to stimuli that cause gamma interferon synthesis, we also plan to investigate whether thymocytes acquire other immune functions characteristic of mature T lymphocytes when interferon synthesis is induced. It is our goal to investigate the immunoregulatory functions of gamma interferon, in particular its effect on T-cell-dependent immunoglobulin synthesis by thymocytes. Furthermore, we continue our investigation of the relationship between interleukin-2 and gamma interferon synthesis and the pharmacologic regulation of gamma IFN synthesis. The mechanism of induction of gamma interferon is of crucial importance for the understanding of one of the factors that influence host response to invasion by tumor cells in lines. (IS)

本研究的目的是研究诱导的机制， 人胸腺细胞体外合成γ干扰素。 它是基于 我们最初观察到人类胸腺细胞可以被诱导合成 两种干扰素：凝集素和B淋巴母细胞产物 线 这是第一次观察到γ干扰素的诱导， 淋巴因子，通过T淋巴细胞的前体。 我们的目标是确定 诱导的胸腺细胞亚群， 干扰素合成与其他免疫功能的获得 成熟T淋巴细胞的特征。 T淋巴细胞起着关键作用 在细胞免疫防御中，胸腺细胞在免疫防御中的募集 对病原体或肿瘤细胞的防御可能是至关重要的。 在 胸腺细胞对引起γ干扰素的刺激的反应的看法 合成，我们还计划研究胸腺细胞是否获得其他 当干扰素作用时，成熟T淋巴细胞免疫功能特征 合成是诱导的。 我们的目标是研究免疫调节 γ干扰素的功能，特别是其对T细胞依赖性 胸腺细胞合成免疫球蛋白。 此外，我们继续调查 白细胞介素-2和γ干扰素的合成及其药理学 γ IFN合成的调节。 γ-干扰素的诱导机制对于 了解影响宿主对病毒反应的因素之一， 肿瘤细胞呈直线侵入。 （IS）