GENETIC LINKAGE IN MULTIPLE ENDOCRINE NEOPLASIA, TYPE II

II 型多发性内分泌肿瘤中的遗传连锁

• 批准号: 3170106
• 负责人: MYRON GENEL
• 金额: $ 14.95万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1983
• 资助国家: 美国
• 起止时间: 1983-06-01 至 1987-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3170106
• 关键词: biological polymorphism; cancer prevention; cancer risk; carcinoma; early diagnosis; endocrine neoplasm; genetic manipulation; human population genetics; human subject; linkage mapping; molecular cloning; molecular oncology; neoplasm /cancer diagnosis; neoplasm /cancer genetics; pheochromocytoma; preneoplastic state; thyroid neoplasm

The goal of this research is to seek identifiable genetic markers whose inheritance is linked with that of multiple endocrine neoplasia, type II (MEN II), and to screen individuals to detect preclinical onset of the disease. Approximately 240 individuals will be screened for a wide variety of genetic markers in the attempt to identify genetic marker loci that are closely linked to the locus at which the cancer gene is segregating. This information will be used to identify individuals at high risk for inheriting the gene. Endocrinological screening is continued in the attempt to detect early manifestations of the disease in sufficient time so that advanced carcinoma can be avoided. (5)

本研究的目的是寻找可识别的遗传标记，其