II 型多发性内分泌肿瘤中的遗传连锁-猫眼课题宝

II 型多发性内分泌肿瘤中的遗传连锁

批准号：

3170106

负责人：

MYRON GENEL

金额：

$14.95万

依托单位：

YALE UNIVERSITY

依托单位国家：

美国

项目类别：

财政年份：

1983

资助国家：

美国

项目状态：

已结题

起止时间：

1983-06-01 至 1987-05-31

来源：

https://reporter.nih.gov/project-details/3170106

关键词：

biological polymorphism cancer prevention cancer risk carcinoma early diagnosis endocrine neoplasm genetic manipulation human population genetics human subject linkage mapping molecular cloning molecular oncology neoplasm /cancer diagnosis neoplasm /cancer genetics pheochromocytoma preneoplastic state thyroid neoplasm

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英文摘要

The goal of this research is to seek identifiable genetic markers whose inheritance is linked with that of multiple endocrine neoplasia, type II (MEN II), and to screen individuals to detect preclinical onset of the disease. Approximately 240 individuals will be screened for a wide variety of genetic markers in the attempt to identify genetic marker loci that are closely linked to the locus at which the cancer gene is segregating. This information will be used to identify individuals at high risk for inheriting the gene. Endocrinological screening is continued in the attempt to detect early manifestations of the disease in sufficient time so that advanced carcinoma can be avoided. (5)

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