MONITORING MEDULLARY THYROID CARCINOMA IN A LARGE KINDRED WITH MEN 2A

这是一项长期的研究，持续了30年的一个大家族与 131名成员，其中一些人患有遗传性甲状腺和肾上腺 癌症。钙/五肽胃泌素输注筛查家系成员 和使用限制片段长度多态性的连锁作图 研究已经将该基因与10号染色体着丝粒联系起来。 现在正在与决定性的聚合酶链式反应分析相关联， Ret基因。

This is a long standing study of 30 years duration of a large kindred with 131 members, some of whom have the hereditary form of thyroid and adrenal cancer. Screening of family members with a calcium/pentagastrin infusion and linkage mapping using restriction fragment length polymorphism in this study has linked the gene to the centromere of chromosome #10. This data is now being correlated with definitive PcR analysis for mutating in the RET gene.