MONITORING MEDULLARY THYROID CARCINOMA IN A LARGE KINDRED WITH MEN 2A

监测男性大家族中的甲状腺髓样癌 2A

• 批准号: 6282639
• 负责人: MYRON GENEL
• 金额: $ 0.62万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6282639
• 关键词: adrenal neoplasm; calcium; clinical research; family genetics; gene mutation; human genetic material tag; human subject; linkage mapping; medullary thyroid carcinoma; neoplasm /cancer genetics; polymerase chain reaction; restriction fragment length polymorphism

This is a long standing study of 30 years duration of a large kindred with 131 members, some of whom have the hereditary form of thyroid and adrenal cancer. Screening of family members with a calcium/pentagastrin infusion and linkage mapping using restriction fragment length polymorphism in this study has linked the gene to the centromere of chromosome #10. This data is now being correlated with definitive PcR analysis for mutating in the RET gene.

这是一项长期的研究，持续了30年， 131名成员，其中一些人患有甲状腺和肾上腺的遗传形式 癌 通过钙/五肽胃泌素输注筛查家庭成员 和使用限制性片段长度多态性的连锁图谱， 一项研究将该基因与10号染色体的着丝粒联系起来。 该数据 现在正与明确的PcR分析相关联， RET基因。