EPIDEMIOLOGY OF MALE BREAST CANCER

男性乳腺癌的流行病学

• 批准号: 3173246
• 负责人: David D Thomas
• 金额: $ 10.14万
• 依托单位: FRED HUTCHINSON CANCER RESEARCH CENTER
• 依托单位国家: 美国
• 财政年份: 1983
• 资助国家: 美国
• 起止时间: 1983-09-15 至 1988-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3173246
• 关键词: Klinefelter's syndrome; adult human (21+); breast neoplasms; cancer registry /resource; cancer risk; case history; diet; gynecomastia; hormone related neoplasm /cancer; interview; male; nutrition related tag; questionnaires; radiation carcinogen; reproductive hormone; statistics /biometry

A population-based case-control study of male breast cancer is proposed to: a) elucidate risk factors for breast cancer other than those related to menstruation and childbearing; and b) provide additional information on the role of hormonal factors in the genesis of breast cancer. Eligible cases will be all adult males who develop breast cancer from 1 July, 1983 to 30 June, 1986, and who reside in areas covered by 9 population-based cancer registries in the United States funded by the Surveillance, Epidemiology and End Results (SEER) program of the National Cancer Institute. A random digit dialing technique will be utilized to select two controls per case from among residents of the same counties in which the cases reside. All study subjects will be interviewed to ascertain: a history of a variety of factors related to endogenous sex hormone levels, use of exogenous sex and other hormones, use of drugs that may cause gynecomastia, family history of breast diseases and cancer, exposure to ionizing radiation, selected dietary factors, and history of prior neoplasms. Medical records of the cases will be reviewed to ascertain evidence of Klinefelter's syndrome and concurrent gynecomastia, and slides from all cases will be reviewed and classified by a single pathologist. Data processing and analysis will be performed at a Coordinating Center in Seattle. Both stratification and multivariate techniques will be used to estimate relative risks of breast cancer in relation to the various hormonal and non-hormonal variables considered.

本文提出了一个以人群为基础的男性乳腺癌病例对照研究 a）阐明乳腺癌的风险因素，而不是相关因素 月经和生育;和B）提供关于以下方面的额外信息 激素因素在乳腺癌发生中的作用。 资格 病例将为1983年7月1日以后发生乳腺癌的所有成年男性 1986年6月30日至 在美国的癌症登记处， 国家癌症流行病学和最终结果（SEER）计划 院 将利用随机数字拨号技术选择两个 控制每例来自同一县的居民，其中 案件居住。 将对所有研究受试者进行访谈，以确定：a 多种因素的病史与内源性性激素水平有关， 使用外源性激素和其他激素，使用可能导致 男性乳房发育，乳腺疾病和癌症家族史，暴露于 电离辐射、选定的饮食因素和既往病史 肿瘤。 我们会覆检有关个案的医疗纪录， 克氏综合征和并发男性乳房发育的证据，以及载玻片 将由一名病理学家对所有病例进行审查和分类。 数据处理和分析将在协调中心进行， 西雅图。 分层和多变量技术都将用于 估计乳腺癌的相对风险与各种 考虑激素和非激素变量。

项目成果

Efficient selection of controls for multi-centered collaborative studies of rare diseases.

罕见疾病多中心协作研究的有效对照选择。

• DOI: 10.1093/oxfordjournals.aje.a114320
• 发表时间: 1986
• 期刊: American journal of epidemiology
• 影响因子: 5
• 作者: McTiernan,A;Thomas,DB;Whitehead,A;Noonan,E
• 通讯作者: Noonan,E

The relationship between diet and breast cancer in men (United States).

饮食与男性乳腺癌的关系（美国）。

• DOI: 10.1023/a:1008808925665
• 发表时间: 1999
• 期刊: Cancer causes & control : CCC
• 作者: Rosenblatt,KA;Thomas,DB;Jimenez,LM;Fish,B;McTiernan,A;Stalsberg,H;Stemhagen,A;Thompson,WD;Curnen,MG;Satariano,W;Austin,DF;Greenberg,RS;Key,C;Kolonel,LN;West,DW
• 通讯作者: West,DW