ANALOG CODED SYSTEMS FOR POSITRON TOMOGRAPHY

用于正电子断层扫描的模拟编码系统

• 批准号: 3170746
• 负责人: GORDON L BROWNELL
• 金额: $ 32.17万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1981
• 资助国家: 美国
• 起止时间: 1981-08-01 至 1988-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3170746
• 关键词: computer assisted diagnosis; image processing; noninvasive diagnosis; nuclear medicine; positron emission tomography; radionuclide diagnosis; radionuclide emission tomography; radionuclide imaging /scanning; whole body radionuclide scanning

Positron tomography has reached a critical point in its development. Numerous studies have shown that this technique can produce useful information in animal and man that cannot be provided by any other imaging system. However, positron imaging has been limited because of relatively poor resolution. We have developed powerful techniques of analog coding which permits the design of high resolution instruments. PCR-I is an analog coded single ring prototype system for positron tomography. The system currently is operating at 4.5mm resolution without the use of interpolative motion. Studies are underway using phantoms and animal systems to study areas of application of this instrument. This instrument shows high resolution, high sensitivity, relatively low random and prompt scatter coincidence rates and excellent stability and linearity. Based on the design of PCR-I, we propose to develop an analog coded cylindrical positron tomograph to image volume distributions of positron emitting activity. Physical studies will be carried out using Monte Carlo calculations and experiments to determine the effects of randoms and prompt scatter coincidences. Studies will be carried out for different source geometries and activity levels. By use of a powerful simulation program, the design parameters of PCR-II, an analog coded cylindrical positron tomograph, will be determined. Again, by use of simulation, the performance of the instrument will be predicted for different imaging tasks. PCR-II will provide an instrument with resolution approaching the physical limitations of positron range and small angle deviation and yielding very high sensitivity and count rate capability. The two dimensional analog coding permits each phototube to identify a large number of detector elements, thus permitting a design with thousands of detectors. The system will also operate without interpolative motion. Stability and linearity should be equal to that of PCR-I. A three dimensional reconstruction algorithm will be used to reconstruct the source distribution within the volume source. The problems encountered in use of this algorithm will be investigated again by simulation.

正电子断层扫描技术的发展已经到了一个临界点。 许多研究表明，这种技术可以产生有用的 任何其他成像都不能提供动物和人的信息 系统 然而，正电子成像受到限制， 分辨率差。 我们开发了强大的模拟编码技术 这允许设计高分辨率仪器。 PCR-I是一个模拟编码的单环原型系统， 断层扫描 该系统目前以4.5mm分辨率运行， 插值运动的使用。 研究正在进行中， 动物系统，以研究该仪器的应用领域。 这 仪器分辨率高、灵敏度高、随机性相对较低 散射符合率快、稳定性和线性好。 在PCR-I设计的基础上，提出了一种模拟编码的 对正电子的体积分布成像的圆柱形正电子断层摄影机 发射活动。 物理研究将使用蒙特卡罗方法进行 计算和实验，以确定随机和提示的影响， 分散的巧合 将对不同来源进行研究 几何形状和活动水平。 通过使用功能强大的仿真程序， 模拟编码圆柱正电子探针PCR-II的设计参数 将被确定。 再次，通过使用模拟， 将针对不同的成像任务预测仪器的性能。 PCR-II将提供一种分辨率接近物理分辨率的仪器。 正电子范围和小角度偏差的限制， 高灵敏度和计数率能力。 二维模拟 编码允许每个光电管识别大量的探测器 元件，从而允许具有数千个检测器的设计。 系统 也将在没有内插运动的情况下操作。 稳定性和线性 应与PCR-1的结果相同。 将使用三维重建算法来重建 卷源内的源分布。 遇到的问题 将通过仿真再次研究该算法的使用。