STUDIES ON NEUTRON CAPTURE THERAPY (MIT)

中子捕获疗法研究（麻省理工学院）

• 批准号: 3180113
• 负责人: GORDON L BROWNELL
• 金额: $ 12.1万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-09-30 至 1986-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3180113
• 关键词: autoradiography; high energy particle; ionizing radiation; neoplasm /cancer radiation therapy; neutron radiation; phantom model; radiation sensitivity; radiation therapy dosage; relative biological effectiveness; scanning electron microscopy

The research program is designed to provide information on basic aspects of neutron capture therapy. This information will provide the basis for application of NCT in therapy of many diseases. The first portion of the study deals with the optimal design of an epithermal neutron source suitable for use in a hospital environment. The availability of epithermal neutrons will permit NCT to be employed in brain and in other organs without surgery. Fractionated therapy may be possible. Track etch autoradiography will be used to determine the distribution of compounds on a cellular basis in biological tissue. The technique will be used with scanning and transmission electron microscopy to determine radiobiological response. Track etch autoradiography will also be employed to determine the biodistribution of boron labelled compounds on a macroscopic basis. The possible use of positron emission tomography to quantitate concentrations of boron compounds in tissues will be investigated.

该研究计划旨在提供有关基本方面的信息， 中子俘获疗法 这些信息将为 NCT在多种疾病治疗中的应用。 研究的第一部分涉及一个 超热中子源，适用于医院环境。 的 超热中子的可用性将允许NCT用于大脑 以及其他器官的感染 分次治疗是可能的。 径迹蚀刻放射自显影将用于确定 在生物组织中以细胞为基础的化合物。 这项技术将是 与扫描和透射电子显微镜一起使用， 放射生物反应 还将采用径迹蚀刻放射自显影术 为了确定硼标记化合物在 宏观基础 正电子发射断层扫描可能用于 组织中硼化合物的定量浓度将 研究了