CELL MORPHOLOGY IN FOLLICULAR AND DIFFUSE LYMPHOMAS

恶性淋巴瘤的组织病理学诊断是基于一个大的 根据细胞学的形态学分析确定程度。 在证明了 计算机组织形态测量使得分析细胞形态成为可能 在人类肝脏组织的普通石蜡切片中， 应Bharat Nathwani博士的要求， 南加州大学医学院，使用人体切片 淋巴结组织 已经取得了可喜的成果。 现在 我希望在50至150例新病例中完成这项研究，并比较 淋巴瘤病理学检查组目视测定结果 临床研究。 比较研究将包括至少25个案例 滤泡性淋巴瘤和至少25例弥漫性淋巴瘤。 后 在初始阶段，已经开发的试验计算机程序用于： (1)滤泡（结节）的位置;（2）细胞计数 形态的细化，他们进行了统计比较，与那些已经 由专家组获得。 机器速度、精度和生产率将 测量和NCI准备的报告。 这个项目的参与者 将是电子工程系， 解剖病理学系，医学院，大学 南加州;和放射卫生部， 匹兹堡公共卫生学院。 梅伦大学和 匹兹堡大学将提供计算设施和 全自动显微镜，而医学院，大学 南加州将提供医疗咨询， 所有病理材料的来源。 从长远来看，我们希望： (1)评价自动显微镜在提供 病理学家与定量细胞学和组织学数据;（2）研究 在病理学家和 机器人显微镜;（3）为自动化细胞的未来研究做准备 分化和在人体组织结构分析中的应用 淋巴结 （三）

The histopathologic diagnosis of malignant lymphomas is based to a large extent upon morphologic analysis of the cytology. After demonstrating that computed tissue morphometry makes it possible to analyze cell morphology within ordinary paraffin sections of human liver tissue, Carnegie-Mellon has conducted a pilot project at the request of Dr. Bharat Nathwani, Medical School, University of Southern California, using sections of human lymph node tissue. Promising results have been obtained. It is now desired to complete this study on 50 to 150 new cases and to compare the results with the visual determinations of the Pathology Panel for Lymphoma Clinical Studies. The comparative study would encompass at least 25 cases of follicular lymphoma and at least 25 cases of diffuse lymphoma. After an initial phase wherein the already developed pilot computer programs for: (1)\the location of follicles (nodules), and (2)\the measurement of cell morphology are refined, they are compared statistically with those already obtained by the panel. Machine speed, accuracy, and producibility will be measured and a report prepared by NCI. The participants in this program will be the Department of Electrical Engineering, Carnegie-Mellon University; Division of Anatomic Pathology, Medical School, University of Southern California; and the Department of Radiation Health, University of Pittsburgh School of Public Health. Carnegie-Mellon University and the University of Pittsburgh will provide the computation facilities and the fully automated microscope, while the Medical School, University of Southern California will provide medical consultation and will be the source of all pathologic material. In the long term, we hope to: (1)\evaluate the potential of automated microscope in furnishing the pathologist with quantitative cytologic and histologic data; (2)\study methods of forming an interactive partnership between the pathologist and the robot microscope; and (3)\prepare for future research in automated cell differentiation and in the analysis of tissue architecture in the human lymph node. (3)