BrisSynBio: Bristol Centre for Synthetic Biology

BrisSynBio：布里斯托尔合成生物学中心

• 批准号: BB/L01386X/1
• 负责人: Dek Woolfson
• 金额: $ 2006.41万
• 依托单位: University of Bristol
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2014
• 资助国家: 英国
• 起止时间: 2014 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FL01386X%2F1
• 关键词: BrisSynBio; Bristol; Centre; Synthetic; Biology

Synthetic biology is a new scientific discipline that aims to make the engineering of biological systems easier, more predictable and more reliable. Synthetic biologists aim to develop new techniques, technologies and reagents that will allow biological or biologically based products to be made easily, quickly and cheaply, and in sufficient quantities to make them useful. Advances in this area have the potential to provide us with new fuels, materials, diagnostics and medicines, and offer solutions to many of the major global challenges that we face today. For example providing sufficient food for the world's population and reducing our dependence on fossil fuels.For synthetic biology to meet these challenges, however, will require the concerted efforts of large groups of scientists working together in teams combining their expertise, skills and knowledge. To achieve this we aim to establish BrisSynBio (BSB), a Bristol-based Synthetic Biology Research Centre, which will bring together a group of scientists from a range of different research backgrounds, e.g. biology, chemistry, computer science, engineering and robotics, mathematics and physics.BSB researchers will combine their expertise in such a way that global challenges can be met and resolved. Examples of the type of work that BSB scientists will carry out include: modifying biosynthetic pathways in microorganisms such to produce new antibiotics; assembling virus-like particles to present new routes to vaccines; building simple cells from scratch for use in the production of important but sometimes toxic chemicals; using red blood cells to deliver complex molecules like anti-cancer drugs directly to tumours; and reprograming bacteria to perform useful tasks like sensing environmental pollutants.Within the BSB, researchers will be organised into teams with complementary skills who will work together on these challenging projects. There will be lots of communication between the teams, and new and exciting research will emerge as a result. Teams will be linked together by cross-cutting themes to promote interdisciplinarity and exchange of ideas. To help foster and develop interactions further, BSB academics will attend monthly discussion meetings, and all BSB academics and researchers will attend monthly research seminars and an annual 2-day regional symposium.The University of Bristol has recently invested heavily in new buildings and laboratory space, perfect for housing BSB. Now we need further investment to purchase the essential equipment that we will need to underpin and progress our research, and also to attract more scientists to expand synthetic-biology activities. We will also work in collaboration with a range of different project partners including researchers form around the world, the public and policy makers, and industrialists, such that we can maximise the impact of BrisSynBio.Finally, synthetic biology is not without controversy, the notion of tinkering with biology and life does not sit comfortably with everyone. Therefore, it is very important that all BrisSynBio members are trained to consider the ethical, legal and social implications of their work, placing it in a broader societal context. To achieve this BSB members will be trained in responsible innovation and public engagement, and encouraged to put these new skills into practice through commercialising their work where appropriate, and at 6-monthly science cafes and public dialogues.

合成生物学是一门新的科学学科，旨在使生物系统的工程更容易，更可预测和更可靠。合成生物学家的目标是开发新的技术，技术和试剂，使生物或生物基产品能够容易，快速和廉价地制造，并以足够的数量使它们有用。这一领域的进展有可能为我们提供新的燃料、材料、诊断方法和药物，并为我们今天面临的许多重大全球挑战提供解决方案。例如，为世界人口提供充足的食物，减少我们对化石燃料的依赖。然而，合成生物学要应对这些挑战，需要大量科学家的共同努力，他们在团队中结合自己的专业知识、技能和知识。为了实现这一目标，我们的目标是建立一个位于布里斯托尔的合成生物学研究中心，该中心将汇集一批来自不同研究背景的科学家，例如生物学、化学、计算机科学、工程和机器人技术、数学和物理学。BSB研究人员将联合收割机结合他们的专业知识，以应对和解决全球挑战。BSB科学家将开展的工作类型的例子包括：修改微生物中的生物合成途径，例如生产新的抗生素;组装病毒样颗粒，为疫苗提供新的途径;从头开始构建简单的细胞，用于生产重要但有时有毒的化学物质;使用红细胞将复杂的分子，如抗癌药物直接输送到肿瘤。以及重新编程细菌以执行有用的任务，如感知环境污染物。在BSB内，研究人员将被组织成具有互补技能的团队，他们将共同致力于这些具有挑战性的项目。团队之间将有大量的沟通，新的和令人兴奋的研究将因此出现。团队将通过交叉主题联系在一起，以促进跨学科和思想交流。为了进一步促进和发展互动，BSB学者将参加每月的讨论会，所有BSB学者和研究人员将参加每月的研究研讨会和每年为期2天的区域研讨会。布里斯托大学最近投入巨资建造新的建筑和实验室空间，非常适合BSB。现在我们需要进一步投资来购买支撑和推进我们的研究所需的基本设备，并吸引更多科学家来扩大合成生物学活动。我们还将与一系列不同的项目合作伙伴合作，包括来自世界各地的研究人员，公众和政策制定者以及工业家，这样我们就可以最大限度地发挥合成生物学的影响。最后，合成生物学并非没有争议，修补生物学和生命的概念并不适合每个人。因此，非常重要的一点是，所有的Bio SynBio成员都要接受培训，以考虑他们工作的伦理、法律的和社会影响，并将其置于更广泛的社会背景下。为了实现这一目标，BSB成员将接受负责任的创新和公众参与方面的培训，并鼓励他们通过适当的商业化工作，以及在6个月的科学咖啡馆和公众对话中将这些新技能付诸实践。

项目成果

Biomolecular Simulations in the Time of COVID19, and After.

• DOI: 10.1109/mcse.2020.3024155
• 发表时间: 2020-11
• 期刊: Computing in science & engineering
• 影响因子: 2.1
• 作者: Amaro RE;Mulholland AJ
• 通讯作者: Mulholland AJ

Heterologous expression reveals the biosynthesis of the antibiotic pleuromutilin and generates bioactive semi-synthetic derivatives.

• DOI: 10.1038/s41467-017-01659-1
• 发表时间: 2017-11-28
• 期刊: Nature communications
• 影响因子: 16.6
• 作者: Alberti F;Khairudin K;Venegas ER;Davies JA;Hayes PM;Willis CL;Bailey AM;Foster GD
• 通讯作者: Foster GD

Entropy of Simulated Liquids Using Multiscale Cell Correlation.

• DOI: 10.3390/e21080750
• 发表时间: 2019-07-31
• 期刊: Entropy (Basel, Switzerland)
• 作者: Ali HS;Higham J;Henchman RH
• 通讯作者: Henchman RH