13TSB_AgriFood: Optimising the delivery of superior genetics through advanced genomic selection of bovine embryos
13TSB_AgriFood:通过牛胚胎的高级基因组选择优化卓越遗传学的传递
基本信息
- 批准号:BB/L017415/1
- 负责人:
- 金额:$ 16.12万
- 依托单位:
- 依托单位国家:英国
- 项目类别:Research Grant
- 财政年份:2014
- 资助国家:英国
- 起止时间:2014 至 无数据
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
This proposal is a natural but significant extension of two existing TSB funded projects involving the two collaborating academic institutions (i.e. TS/101069 ['Applying advanced breeding technologies to amplify and distribute bovine genetics to increase production efficiency and sustainability', involving the University of Nottingham], and TS/J003182/1 [Pig IVF and genetics: a route to global sustainability, involving the University of Kent]) to develop advanced breeding technologies in cattle with commercial partners (i.e. Paragon/XLVets, Cogent Breeding Ltd and Illumina Inc) that will allow the marketing of embryos that have undergone a complete genomic evaluation (including sexing) in order to estimate the breeding value of progeny for traits of commercial importance at the earliest possible stage of development.This project will apply advanced breeding technologies to produce (both in-vivo and in-vitro) pre-implantation bovine embryos from which biopsies will be taken to interrogate their genomic makeup using single nucleotide polymorphism arrays (SNP chips). It is currently possible to screen dairy and beef cattle genomically, but responses to selection are impeded by waiting for the gestation of the calf on which genomic selection is performed. The screening of bovine embryos, however, would optimise the delivery and amplification of superior genetics by advancing the time of selection and reducing "wastage" of unwanted calves of inappropriate sex. This project will, therefore, combine advanced embryo breeding technologies with state-of-the-art genomic screening (so called pre-implantation genetic diagnosis), and karyomapping (combining parental DNA information with the offspring's genomic information to provide more genetic detail). It will develop strategies for: (i) optimal bovine embryo culture using sexed semen, (ii) embryo biopsy in order to extract a small number of blastomeres for genomic analysis, (iii) karyomapping SNP genotype data from Multiple Displacement Amplification products and (iv) ehnancing pregnancy establishment of frozen-thawed embryos. Proof of principle that the new technologies can be used to deliver superior genetics more efficiently to the breeding herd will be confirmed by conducting genomic analyses of calves.Importantly, this project is geared towards the development and use of a unique and highly marketable product (i.e. genetically evaluated sexed embryos) that will deliver superior genetics to the global market at low cost, and in a high-welfare and bio-secure manner. This will have huge economic benefits for the UK based commercial companies concerned, and for both the dairy and beef sectors of the UK cattle industry; and ensure that the UK remains at the cutting edge of technical innovation retaining its competitive advantage over larger breeding companies currently situated in Europe, North and South America.
该提案是TSB资助的两个现有项目的自然但重要的延伸,涉及两个合作学术机构(即TS/101069[“应用先进育种技术来扩增和传播牛遗传学以提高生产效率和可持续性”,涉及诺丁汉大学]和TS/J003182/1[猪体外受精和遗传学:与商业合作伙伴(如Paragon/XLVets、Cogent breeding Ltd和Illumina Inc)一起开发先进的牛育种技术,这些技术将允许销售经过完整基因组评估(包括性别鉴定)的胚胎,以便在尽可能早的发育阶段估计后代具有商业重要性的性状的育种价值。该项目将应用先进的育种技术来生产(体内和体外)植入前的牛胚胎,利用单核苷酸多态性阵列(SNP芯片)对其进行活组织检查,以询问其基因组组成。目前对奶牛和肉牛进行基因筛选是可能的,但对选择的反应受到等待小牛妊娠的阻碍,因为要对小牛进行基因组选择。然而,牛胚胎的筛选将通过提前选择时间和减少不合适性别的不需要的小牛的“浪费”来优化优良基因的传递和扩增。因此,该项目将把先进的胚胎育种技术与最先进的基因组筛选(即所谓的植入前遗传学诊断)和核作图(将亲代DNA信息与后代基因组信息相结合,以提供更多的遗传细节)结合起来。它将制定以下策略:(i)使用性别精液进行最佳牛胚胎培养,(ii)胚胎活检以便提取少量卵裂球进行基因组分析,(iii)从多重位移扩增产品中提取SNP基因型数据的核定位,(iv)加强冻融胚胎的妊娠建立。通过对小牛进行基因组分析,可以证实新技术可以更有效地向繁殖群传递优良基因的原理。重要的是,该项目旨在开发和使用一种独特的、高度市场化的产品(即基因评估的性别胚胎),以低成本、高福利和生物安全的方式向全球市场提供优越的基因。这将为英国的相关商业公司带来巨大的经济利益,并为英国畜牧业的乳制品和牛肉部门带来巨大的经济利益;并确保英国保持在技术创新的前沿,保持其相对于目前位于欧洲、北美和南美的大型育种公司的竞争优势。
项目成果
期刊论文数量(5)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Analysis of the presence of mosaicism in bovine embryos through Preimplantation genetic testing (PGT-A) algorithms.
通过植入前基因检测 (PGT-A) 算法分析牛胚胎中嵌合体的存在。
- DOI:
- 发表时间:2022
- 期刊:
- 影响因子:0
- 作者:Canedo-Ribeiro C
- 通讯作者:Canedo-Ribeiro C
Aneuploidy screening in inner-cell mass and trophectoderm lineages of bovine blastocysts derived from stimulated and non-stimulated ovarian cycles
来自刺激和非刺激卵巢周期的牛囊胚的内细胞团和滋养外胚层谱系的非整倍性筛查
- DOI:
- 发表时间:2020
- 期刊:
- 影响因子:0
- 作者:Tutt DAR
- 通讯作者:Tutt DAR
CASA and flow-cytometric parameters of semen for use in bovine in vitro embryo production (IVP)
用于牛体外胚胎生产 (IVP) 的精液 CASA 和流式细胞仪参数
- DOI:
- 发表时间:2020
- 期刊:
- 影响因子:0
- 作者:Dodd PC
- 通讯作者:Dodd PC
Effects of single or serial embryo splitting on the development and morphokinetics of in vitro produced bovine embryos
单个或连续胚胎分裂对体外牛胚胎发育和形态动力学的影响
- DOI:10.1080/24750263.2022.2077994
- 发表时间:2022
- 期刊:
- 影响因子:0
- 作者:Silvestri G
- 通讯作者:Silvestri G
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Kevin Sinclair其他文献
Generalizations of Coarse Properties in Large Scale Spaces
- DOI:
- 发表时间:
2017 - 期刊:
- 影响因子:0
- 作者:
Kevin Sinclair - 通讯作者:
Kevin Sinclair
10:00-10:20 Reproductive function in a polluted world: lessons from animal models
- DOI:
10.1016/j.jri.2022.103563 - 发表时间:
2023-08-01 - 期刊:
- 影响因子:
- 作者:
Richard G Lea;Rebecca Sumner;Morne Van der Mescht;Deborah Adi;David Gardner;Kevin Sinclair;Gary England - 通讯作者:
Gary England
EMPLOYING THE MULTIDISCIPLINARY HEART TEAM APPROACH FOR COMPLEX CORONARY ARTERY DISEASE: A SINGLE CENTER EXPERIENCE
- DOI:
10.1016/s0735-1097(17)35933-8 - 发表时间:
2017-03-21 - 期刊:
- 影响因子:
- 作者:
Michael Young;Elizabeth Laikhter;Kevin Sinclair;Mary Cadigan;Eugene Pomerantsev;Michael Fifer;Thoralf Sundt;Robert Yeh;Farouc Jaffer - 通讯作者:
Farouc Jaffer
Developmental programming: Sex-specific effects of prenatal exposure to a real-life mixture of environmental chemicals on liver function and transcriptome in sheep
发育编程:产前暴露于现实生活中环境化学物质混合物对绵羊肝功能和转录组的性别特异性影响
- DOI:
10.1016/j.envpol.2025.125630 - 发表时间:
2025-02-15 - 期刊:
- 影响因子:7.300
- 作者:
Soundara Viveka Thangaraj;Michelle Bellingham;Richard Lea;Neil Evans;Kevin Sinclair;Vasantha Padmanabhan - 通讯作者:
Vasantha Padmanabhan
TCT-505 Feasibility of a Novel Echo/X-Ray Fusion Software to Determine Implant Angulation during Transcatheter Aortic Valve Replacement
- DOI:
10.1016/j.jacc.2016.09.641 - 发表时间:
2016-11-01 - 期刊:
- 影响因子:
- 作者:
Kevin Sinclair;Daniel Bamira;Erin Girard;Michael Szucs;Ryan Spilker;Sammy Elmariah;Jonathan Passeri;Ignacio Inglessis - 通讯作者:
Ignacio Inglessis
Kevin Sinclair的其他文献
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{{ truncateString('Kevin Sinclair', 18)}}的其他基金
In vitro embryo production in animal breeding: Enhancing oocyte quality from peri-pubertal donors to promote biosecure and sustainable food production
动物育种中的体外胚胎生产:提高青春期前后捐献者的卵母细胞质量,以促进生物安全和可持续粮食生产
- 批准号:
BB/R007985/1 - 财政年份:2018
- 资助金额:
$ 16.12万 - 项目类别:
Research Grant
Genetics of one-carbon metabolism in sheep in relation to productivity, fertility and health
绵羊一碳代谢遗传学与生产力、生育力和健康的关系
- 批准号:
BB/K017810/1 - 财政年份:2013
- 资助金额:
$ 16.12万 - 项目类别:
Research Grant
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