TUMOR DIAGNOSIS BY RAPID DNA PLOIDY PATTERN ANALYSIS

细胞学和组织学标本中细胞核的DNA倍体模式 将用于提供肿瘤诊断和预后信息。我们的 快速、计算机控制、基于视频的显微光度计系统使 在几分钟内记录DNA倍体模式，具有统计有效性 样本量，从而使这种有价值的方法作为例行公事而切实可行 临床实验室检查。其目的是使方法论标准化 为此，收集和检查临床数据库以进行关联 具有临床意义的倍性模式，以建立客观的衡量标准 用于倍性模式评估，并建立对 非整倍体的检测。一种基于微处理器的廉价显微镜 附件和图形显示已被设计为一种 实用型病理学实验室仪器。(3)

DNA ploidy patterns in cell nuclei from cytologic and histologic samples will be used to provide tumor diagnostic and prognostic information. Our rapid, computer-controlled, video-based microphotometer system allows the recording of DNA-ploidy patterns within minutes, with statistically valid sample sizes, thus making this valuable method practical as a routine clinical laboratory test. It is intended to standardize the methodology for this purpose, to assemble and examine a clinical database to correlate ploidy patterns with clinical implications, to establish objective measures for ploidy pattern evaluation, and to establish the sensitivity for the detection of aneuploidy. An inexpensive, microprocessor-based microscope attachment and graphic display has been designed as a prototype for a practical pathology laboratory instrument. (3)