SUBVISUAL DIAGNOSTIC CLUES IN CANCER DIAGNOSIS

亚视觉标记特征的诊断效用来自 组织病理学和 甲状腺肿瘤患者的细胞病理学样本 宫颈癌前病变和恶性病变将是 测定 视觉正常人标记特征的表达 从细针抽吸物中出现腺核 将对甲状腺进行定量。 空间延伸 标记物特征表达为组织学上正常的外观 组织学切片中病变周围的组织 将测定甲状腺和子宫颈。 早期关于发育不良中表达的标志物特征的工作 子宫颈外细胞将继续和延长，将 组织切片中细胞核的测量。 其预后 预测前驱病变生物学行为的潜力 子宫颈癌的发病率。 将进行探索性研究，以寻找标记物 组织学正常外观粘膜的特征表达 邻近结直肠肿瘤区域。 我们的廉价的分析能力 视频显微光度计将升级，以提取相关 特征，包括核纹理测量。

The diagnostic utility of subvisual marker features derived from microphotometric measurements in histopathological and cytopathological samples for patients with thyroid tumor patients with premalignant and malignant lesions of the cervix will be determined. The expression of marker features in visually normal appearing glandular nuclei from fine needle aspirates of the thyroid will be quantitated. The spatial extension of the expression of marker features into histologically normal appearing tissues surrounding the lesion in histological sections of the thyroid and ectocervix will be determine. Earlier work on the marker features expressed in dysplastic ectocervical cells will be continued and extended, will measurements on nuclei in histologic sections. Their prognostic potential in predicting the biological behavior of precursor lesion of cervical cancer will be explored. An exploratory study will be conducted to search for marker feature expression in histologically normal appearing mucosa adjoining colorectal tumor regions. The analytic capabilities of our inexpensive videomicrophotometer will be upgraded to extract pertinent features, including nuclear texture measures.