Specifying Vascular Pattern in Newly Emerged Roots

指定新出现的根中的维管束模式

• 批准号: BB/L023555/1
• 负责人: Anthony Bishopp
• 金额: $ 50.89万
• 依托单位: University of Nottingham
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2014
• 资助国家: 英国
• 起止时间: 2014 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FL023555%2F1
• 关键词: Specifying; Vascular; Pattern; Newly; Emerged

All plants and animals start life as a single cell. This cell and the subsequent daughter cells then divide to form a multicellular organism. These divisions do not occur at random. They follow a precisely coordinated developmental programme to generate a specific shape or form. Individual cells are instructed to undertake specific cell identities and these various cell types are arranged in specific patterns to create tissues, organs and ultimately an entire organism. In this project we will investigate the genetic mechanisms that generate the positional information upon which a cellular pattern can be superimposed, and specifically on the information is generated to position vascular tissues form within newly formed roots. This project will improve our understanding about how organisms form, but it will also give us detailed insights into vascular development. Plants generate sugars in the leaves and extract water and minerals through their roots. However, it is the vascular tissues (the xylem and phloem) that allow these substances to be transported throughout the plant. These vascular tissues must be arranged in precise patterns to provide a continuous network linking organs within the plant and we will uncover how that pattern is determined.In order to do this, we will generate a series of tools that will allow not only aid our understanding of vascular patterning, but also of many other aspects of root growth. In this project a biologist and mathematician will work together to build a computer programme that can simulate the way that a group of genes behave as a root grows. This will allow us to rapidly test what happens as we change the genetic make up of our computer programme. Using this computational approach we can rapidly test many different patterning mechanisms, allowing us to focus the time consuming experimental analysis on the most important genes. We will make this programme freely available so that other researchers can adapt it to study other types of roots or other processes within the roots.

所有的植物和动物都是从一个单细胞开始的。这个细胞和随后的子细胞分裂形成多细胞生物。这些划分不是随机发生的。它们遵循一个精确协调的发展计划，形成特定的形状或形式。单个细胞被指示承担特定的细胞身份，这些不同类型的细胞以特定的模式排列，形成组织、器官，最终形成整个生物体。在这个项目中，我们将研究产生位置信息的遗传机制，这些信息可以叠加细胞模式，特别是在新形成的根中产生的定位维管组织的信息。这个项目将提高我们对生物如何形成的理解，但它也将使我们对血管发育有更详细的了解。植物在叶子中产生糖，并通过根部提取水和矿物质。然而，是维管组织（木质部和韧皮部）允许这些物质在整个植物中运输。这些维管组织必须以精确的模式排列，以提供一个连接植物内部器官的连续网络，我们将揭示这种模式是如何确定的。为了做到这一点，我们将生成一系列工具，这些工具不仅可以帮助我们理解血管模式，还可以帮助我们理解根生长的许多其他方面。在这个项目中，一位生物学家和一位数学家将共同构建一个计算机程序，以模拟一组基因在根生长时的行为方式。这将使我们能够快速测试当我们改变计算机程序的基因组成时会发生什么。使用这种计算方法，我们可以快速测试许多不同的模式机制，使我们能够将耗时的实验分析集中在最重要的基因上。我们将免费提供这个程序，以便其他研究人员可以将其用于研究其他类型的根或根内的其他过程。

项目成果

Dual expression and anatomy lines allow simultaneous visualization of gene expression and anatomy.

• DOI: 10.1093/plphys/kiab503
• 发表时间: 2022-01-20
• 期刊: Plant physiology
• 影响因子: 7.4
• 作者: Kümpers BMC;Han J;Vaughan-Hirsch J;Redman N;Ware A;Atkinson JA;Leftley N;Janes G;Castiglione G;Tarr PT;Pyke K;Voß U;Wells DM;Bishopp A
• 通讯作者: Bishopp A

A core mechanism for specifying root vascular patterning can replicate the anatomical variation seen in diverse plant species.

指定根维管束模式的核心机制可以复制不同植物物种中观察到的解剖变异。

• DOI: 10.1242/dev.172411
• 发表时间: 2019
• 期刊: Development (Cambridge, England)
• 作者: Mellor N

The innermost secrets of root development

根系发育的最内在秘密

• DOI: 10.1126/science.1257843
• 发表时间: 2014
• 期刊: Science
• 影响因子: 56.9
• 作者: Mellor N

Mobile PEAR transcription factors integrate positional cues to prime cambial growth

• DOI: 10.1038/s41586-018-0839-y
• 发表时间: 2019-01-24
• 期刊: NATURE
• 影响因子: 64.8
• 作者: Miyashima, Shunsuke;Roszak, Pawel;Helariutta, Yka
• 通讯作者: Helariutta, Yka

North, East, South, West: mapping vascular tissues onto the Arabidopsis root.

北、东、南、西：将维管组织映射到拟南芥根上。

• DOI: 10.1016/j.pbi.2017.07.011
• 发表时间: 2018
• 期刊: Current opinion in plant biology
• 影响因子: 9.5
• 作者: Vaughan-Hirsch J