NOVEL ANTIMUTAGENIC COMPOUNDS
NOVEL ANTIMUTAGENIC COMPOUNDS
批准号:
3186003
负责人:
Lester A. Mitscher
金额:
$20.36万
依托单位国家:
美国
项目类别:
财政年份:
1989
资助国家:
美国
项目状态:
已结题
起止时间:
1989-04-01 至 1992-03-31
中文摘要
我们对自然发生的小说进行了一项研究
抗突变剂。 抗诱变剂是单独的化学物质
减少自发或伤害数量的化合物-
在完整细胞群中诱导突变。 这个提议是为了
使用短期测试来筛选;通过生物测定法分离
定向方法;通过光谱确定化学结构
和湿化学方法;确定结构-活性
通过系统合成和化学转化建立关系;
探索生物特性;并探索分子
天然来源的新型抗诱变剂的作用机制。 的
长期目标是制造潜在的化学预防剂
对抗遗传损伤,或许还有癌症。
使用专门为此目的开发的生物测定法,甘草
glabra,一种众所周知的植物,自古以来就被人类用来
它的调味和药用特性,被证明是
可重复活跃。 该活性存在于酚类物质中
馏分和色谱分离后的黄酮类化合物
发现了光甘草烯以及少量的光甘草定和甘草醇
成为活性成分。 产生这些的生物测定
本试验研究的成功结果基于众所周知的
艾姆斯短期沙门氏菌致突变性测定,但经过修改
使用烷化剂(甲磺酸乙酯)诱导
突变。
基于这一成功,建议使用屏幕,
还包括其他诱变治疗,以筛选
相关天然抗突变物质的其他例子
植物并鉴定其活性成分。 一个程序
建议进行化学修饰并结合生物测试,以便
系统地探索结构之间的关系
这些小说系列中的活动。
除了对诱变现象和
据信致突变性发挥作用的其他生物领域
重要作用(衰老、遗传、致癌性、
环境问题)这些化合物可能具有一定的潜力
人类预防医学。
英文摘要
We have undertaken a study of novel naturally occuring
antimutagenic agents. Antimutagens are individual chemical
compounds that decrease the numbers of spontaneous or injury-
induced mutations in intact cell populations. This proposal is to
use short-term tests to screen for; isolate by use of bioassay
directed methodology; determine chemical structure by spectroscopic
and wet chemical methodology of; determine structure-activity
relations by systematic syntheses and chemical transformations of;
explore the biological properties of; and explore the molecular
mechanisms of action of novel antimutagens of natural origin. The
long-term objectives are to make potential chemopreventive agents
against genetic damage and, perhaps, cancer.
Using a bioassay specially developed for the purpose, Glycyrrhiza
glabra, a well known plant used by humans since ancient times for
its flavoring and medicinal properties, was shown to be
reproducably active. The activity was present in the phenolic
fractions and, after chromatographic resolution, the flavanoids
glabrene and, to a lesser extent, glabridin and glabrol, were found
to be the active constituents. The bioassay which produced these
successful results in this trial study is based upon the well known
Ames short-term Salmonella mutagenicity assay but modified through
the use of an alkylating agent (ethyl methanesulfonate) to induce
mutations.
Based upon this success, it is proposed to use the screen, with the
inclusion of other mutagenic treatments as well, to screen for
additional examples of natural antimutagenic substances in related
plants and to identify the active constituents. A program of
chemical modification accompanied by biotesting is proposed so as
to explore in a systematic way the relationship between structure
and activity in these novel series.
In addition to the insights into the mutagenic phenomenon and the
other biological areas where mutagenicity is believed to play an
important role (ageing, heredity, carcinogenicity,
environmental concerns) these compounds may have some potential in
preventive human medicine.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
COBRE: UKS: CORE C: MEDICINAL CHEMISTRY
-
批准号:7959397
-
项目类别:
-
资助金额:$31.0万
-
财政年份:2009
-
负责人:Lester A. Mitscher
-
依托单位:
COBRE: UKS: CORE C: MEDICINAL CHEMISTRY
-
批准号:7720081
-
项目类别:
-
资助金额:$30.55万
-
财政年份:2008
-
负责人:Lester A. Mitscher
-
依托单位:
COBRE: UKS: CORE C: MEDICINAL CHEMISTRY
-
批准号:7609706
-
项目类别:
-
资助金额:$37.56万
-
财政年份:2007
-
负责人:Lester A. Mitscher
-
依托单位:
ANTIMYCOBACTERIAL AGENTS FROM HIGHER PLANTS
-
批准号:2004155
-
项目类别:
-
资助金额:$17.7万
-
财政年份:1995
-
负责人:Lester A. Mitscher
-
依托单位:
ANTIMYCOBACTERIAL AGENTS FROM HIGHER PLANTS
-
批准号:2073061
-
项目类别:
-
资助金额:$17.43万
-
财政年份:1995
-
负责人:Lester A. Mitscher
-
依托单位:
ANTIMYCOBACTERIAL AGENTS FROM HIGHER PLANTS
-
批准号:2073062
-
项目类别:
-
资助金额:$17.03万
-
财政年份:1995
-
负责人:Lester A. Mitscher
-
依托单位:
ANTIMYCOBACTERIAL AGENTS FROM HIGHER PLANTS
-
批准号:2633552
-
项目类别:
-
资助金额:$18.4万
-
财政年份:1995
-
负责人:Lester A. Mitscher
-
依托单位:
DISCOVERY OF NOVEL FUNGICIDAL AGENTS
-
批准号:3547578
-
项目类别:
-
资助金额:$0.0万
-
财政年份:1991
-
负责人:Lester A. Mitscher
-
依托单位:
DISCOVERY OF NOVEL EUNGICIDAL AGENTS
-
批准号:3547579
-
项目类别:
-
资助金额:$42.45万
-
财政年份:1991
-
负责人:Lester A. Mitscher
-
依托单位:
NOVEL ANTIMUTAGENIC COMPOUNDS
-
批准号:3186005
-
项目类别:
-
资助金额:$19.49万
-
财政年份:1989
-
负责人:Lester A. Mitscher
-
依托单位:
NOVEL ANTIMUTAGENIC COMPOUNDS
-
批准号:3186006
-
项目类别:
-
资助金额:$19.84万
-
财政年份:1989
-
负责人:Lester A. Mitscher
-
依托单位:
MEDICINAL CHEMISTRY AND PHARMACOLOGY
-
批准号:3537888
-
项目类别:
-
资助金额:$5.37万
-
财政年份:1979
-
负责人:Lester A. Mitscher
-
依托单位:
MEDICINAL CHEMISTRY AND PHARMACOLOGY
-
批准号:3537894
-
项目类别:
-
资助金额:$14.83万
-
财政年份:1979
-
负责人:Lester A. Mitscher
-
依托单位:
MEDICINAL CHEMISTRY AND PHARMACOLOGY
-
批准号:3537891
-
项目类别:
-
资助金额:$10.55万
-
财政年份:1979
-
负责人:Lester A. Mitscher
-
依托单位:
MEDICINAL CHEMISTRY AND PHARMACOLOGY
-
批准号:3537890
-
项目类别:
-
资助金额:$5.14万
-
财政年份:1979
-
负责人:Lester A. Mitscher
-
依托单位:
MEDICINAL CHEMISTRY AND PHARMACOLOGY
-
批准号:3537893
-
项目类别:
-
资助金额:$12.22万
-
财政年份:1979
-
负责人:Lester A. Mitscher
-
依托单位:
MEDICINAL CHEMISTRY AND PHARMACOLOGY
-
批准号:3537889
-
项目类别:
-
资助金额:$13.77万
-
财政年份:1979
-
负责人:Lester A. Mitscher
-
依托单位:
MEDICINAL CHEMISTRY AND PHARMACOLOGY
-
批准号:3537892
-
项目类别:
-
资助金额:$10.76万
-
财政年份:1979
-
负责人:Lester A. Mitscher
-
依托单位:
NEW ANTIBIOTICS--ISOLATION, SYNTHESIS, AND EVALUATION
-
批准号:2059962
-
项目类别:
-
资助金额:$22.09万
-
财政年份:1976
-
负责人:Lester A. Mitscher
-
依托单位:
NEW ANTIBIOTICS--ISOLATION, SYNTHESIS, AND EVALUATION
-
批准号:3125408
-
项目类别:
-
资助金额:$24.86万
-
财政年份:1976
-
负责人:Lester A. Mitscher
-
依托单位:
海外基金