ANTIMYCOBACTERIAL AGENTS FROM HIGHER PLANTS

来自高等植物的抗真菌剂

• 批准号: 2073061
• 负责人: Lester A. Mitscher
• 金额: $ 17.43万
• 依托单位: UNIVERSITY OF KANSAS LAWRENCE
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-01-01 至 1998-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2073061
• 关键词: Mycobacterium; Mycobacterium tuberculosis; antibacterial agents; antitubercular agents; bioassay; drug design /synthesis /production; microorganism culture; plant extracts; tuberculosis

DESCRIPTION: (Adapted from Applicant's Abstract): The recrudescence of tuberculosis and related mycobacterial diseases coupled with the rise of AIDS presents many difficult problems for society. TB is now often rapidly fatal and is more difficult to control as the strains now are often multiresistant to the drugs normally used for their control. Among the more likely sources of weapons to use in this crisis is the discovery of novel antimycobacterial agents. Using directed screening methods, the applicant has identified higher plant extracts that contain antimycobacterial agents whose structures are novel and comparatively simple, and convenient chemical synthesis has led to a number of analogs with significant activity against multiresistant clinical strains and a number of other, diverse, structural types are advancing toward similar testing. A large number of extracts that have shown in vitro activity against M. smegmatis, M. tuberculosis and M. avium complex in preliminary studies await analysis. The ultimate objective of this proposal is to discover novel potential chemotherapeutic agents for the treatment of mycobacterial infections and to advance them by logical stages into the clinic.

描述：（改编自申请人的摘要）： 结核病和相关的分枝杆菌疾病，加上 艾滋病给社会带来了许多难题。 结核病现在经常 迅速致命，更难以控制，因为现在的菌株是 通常对通常用于控制它们的药物具有多重耐药性。 在这场危机中，最有可能使用的武器来源是 发现新的抗分枝杆菌剂。 使用定向筛选 方法，申请人已经鉴定了含有以下的高等植物提取物： 本发明涉及结构新颖且相对 简单方便的化学合成已经导致了许多类似物 对多重耐药临床菌株具有显著活性， 许多其他的，不同的，结构类型正在朝着类似的方向发展。 试验. 大量的提取物已显示出体外活性 分支杆菌耻垢分枝杆菌M.结核和M.鸟类复合体 初步研究尚待分析。 最终目标是 建议是发现新的潜在的化疗药物， 治疗分枝杆菌感染，并通过合理的 进入诊所。