SYNTHESIS OF PHYSIOLOGICALLY ACTIVE NATURAL PRODUCTS

生理活性天然产物的合成

• 批准号: 3179389
• 负责人: FREDERICK E ZIEGLER
• 金额: $ 17.77万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-09-01 至 1990-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3179389
• 关键词: antileukemic agent; antineoplastic antibiotics; antineoplastics; carcinoma; cytotoxicity; drug design /synthesis /production; lactones; lignans; nasopharyngeal neoplasms; photochemistry; stereochemistry; tissue /cell culture

This proposal seeks to continue current studies in the synthesis of cytotoxic and antineoplastic natural products. New chemical methods are to be developed along with the preparation of substrates for biological evaluation. The completion of the synthesis of eriolanin and eriolangin is planned. Methods developed for the synthesis of aromatin will be applied to fastigilin-type pseudoguaianolides. Experience gained with the Cope-Claisen rearrangement will be utilized in the synthesis of the cytotoxic substance, quadrone. Finally, studies will be started which will be applicable to the synthesis of the antitumor substance, bruceantin.

这项建议旨在继续目前的研究， 具有细胞毒性和毒性的天然产物。 新的化学方法将 沿着生物学用基质的制备 评价 完成了毛蕊花素和毛蕊花苷的合成， 计划好了 将应用为合成芳香素开发的方法 到fastigilin型假愈创木内酯。 从联合国系统获得的经验 Cope-Claisen重排将用于合成 细胞毒性物质，四酮。 最后，将开始研究， 适用于抗肿瘤物质马钱子碱的合成。