SYNTHESIS OF MACROLIDES, TETRAMIC ACIDS, AND VITAMINS

该计划继续研究合成和机械有机材料 化学反应。这些研究具有普遍的医学价值，涉及 抗真菌、抗肿瘤和抗菌物质 和维他命。这种类型的几种物质包括卡霉素B， 替兰霉素、链球菌素、果核红素、蠕虫素 抗生素和维生素E和K将成为机械学的典范 学习。 该计划的一个主要方面涉及到Sigmatrotic重排的使用 控制替兰霉素、链球菌素和维生素的立体化学 工作。发展了钯介导的常温偶联反应 将在本实验室中应用于相关的合成程序 卡莫菌素B，果核杀菌素和蠕虫素。

This program continues investigations in synthetic and mechanistic organic chemistry. These studies are of general medicinal interest relating to substances which are antifungal, antineoplastic, and antibacterial agents and vitamins. Several of the substances of this type include carbomycin B, tirandamycin, streptolydigin, pyrenophorin, vermiculin among the antibiotics and vitamins E and K which will serve as models for mechanistic studies. A major facet of the program involves the use of sigmatropic rearrangments to control stereochemistry in the tirandamycin, streptolydigin, and vitamin work. Palladium-mediated, ambient temperature coupling reactions developed in this laboratory will be applied in the synthetic program related to carbomycin B, pyrenophorin, and vermiculin.