SYNTHESIS OF MACROLIDES, TETRAMIC ACIDS, AND VITAMINS

该计划继续研究合成和机械有机 化学. 这些研究具有普遍的医学意义， 抗真菌剂、抗菌剂和抗细菌剂 和维生素。 几种这种类型的物质包括碳霉素B， 替兰达霉素、利迪霉素、蛋白核转运蛋白、蠕虫蛋白， 抗生素和维生素E和K，这将作为模型的机制， 问题研究 该计划的一个主要方面涉及σ迁移率的使用 来控制替兰霉素、利迪霉素和维生素E中的立体化学， 工作 钯介导的室温偶联反应 在这个实验室将应用于合成程序有关， 碳霉素B、蛋白核转运蛋白和蠕虫蛋白。

This program continues investigations in synthetic and mechanistic organic chemistry. These studies are of general medicinal interest relating to substances which are antifungal, antineoplastic, and antibacterial agents and vitamins. Several of the substances of this type include carbomycin B, tirandamycin, streptolydigin, pyrenophorin, vermiculin among the antibiotics and vitamins E and K which will serve as models for mechanistic studies. A major facet of the program involves the use of sigmatropic rearrangments to control stereochemistry in the tirandamycin, streptolydigin, and vitamin work. Palladium-mediated, ambient temperature coupling reactions developed in this laboratory will be applied in the synthetic program related to carbomycin B, pyrenophorin, and vermiculin.