SYNTHESIS OF MACROLIDES, TETRAMIC ACIDS, AND VITAMINS

大环内酯、四酸和维生素的合成

• 批准号: 3282563
• 负责人: FREDERICK E ZIEGLER
• 金额: $ 13.74万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-06-01 至 1988-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3282563
• 关键词: antibacterial agents; antifungal agents; drug design /synthesis /production; macrolide antibiotics; steroid glycoside aglycone; tocopherols; vitamin K; vitamins

This program continues investigations in synthetic and mechanistic organic chemistry. These studies are of general medicinal interest relating to substances which are antifungal, antineoplastic, and antibacterial agents and vitamins. Several of the substances of this type include carbomycin B, tirandamycin, streptolydigin, pyrenophorin, vermiculin among the antibiotics and vitamins E and K which will serve as models for mechanistic studies. A major facet of the program involves the use of sigmatropic rearrangments to control stereochemistry in the tirandamycin, streptolydigin, and vitamin work. Palladium-mediated, ambient temperature coupling reactions developed in this laboratory will be applied in the synthetic program related to carbomycin B, pyrenophorin, and vermiculin.

这个程序继续研究合成和机械有机