SYNTHETIC STUDIES ON STEROIDS

类固醇的综合研究

• 批准号: 3312748
• 负责人: FREDERICK E ZIEGLER
• 金额: $ 10万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1981
• 资助国家: 美国
• 起止时间: 1981-03-01 至 1987-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3312748
• 关键词: antiinflammatory agents; corticosteroids; cortisone; cyclization; drug design /synthesis /production; estrogen analog; estrone; female antifertility drug; methyl group; neoplasm /cancer chemotherapy; polyenes; prednisone; pregnane compound; progesterone; steroids; testosterone

The methods developed for the synthesis of hormonal and anti-inflammatory steroids will be applied to the synthesis of optically active cortisone and aldosterone. New methods will be explored for the induction of opticla activity through sigmatropic rearrangements. Steroifs play an important role in human health and development as anti-inflammatory, anti-fertility, and symbiotic anti-tumor agents.

荷尔蒙和抗炎药物的合成方法 类固醇将用于合成光学活性可的松和 醛固酮。将探索诱导视疲劳的新方法 通过Sigmatrotic重排的活动。立体图起到了重要的作用 在人类健康和发育中的作用，如抗炎、抗生育、 以及共生抗肿瘤药物。