SPECTROSCOPIC NUCLEAR MAGNETIC RESONANCE IMAGING

能谱核磁共振成像

• 批准号: 3188159
• 负责人: W DIXON
• 金额: $ 5.84万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-09-30 至 1988-08-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3188159
• 关键词: brain imaging /visualization /scanning; clinical biomedical equipment; diagnosis quality /standard; image enhancement; imaging /visualization /scanning; phantom model; phase change; radionuclide diagnosis; radiotracer; spinal cord imaging /visualization

Principles of NMR spectroscopy and imaging will be combined to introduce spectroscopic information into whole body imaging. This will be done for protons (hydrogen) and phosphorus. Chemical shift information can increase contrast greatly in proton images showing lesions not seen without it. When both conventional and spectroscopic proton images show a lesion, spectroscopy always provides chemical information which is not present in the conventional image. Morphology of some tissues such as kidney and CSF may be better shown using new chemical shift weighted gray scales. Spectroscopy allows correction of troublesome artifacts caused by chemical shift differences. In phosphorus imaging these artifacts will be so severe spectroscopy may be a necessity not an enhancement. We have already developed limited fat versus water spectroscopic imaging capability at 0.35 Tesla. This will be extended to higher fields and other substances will be targeted. The method of determining pixel phase from phantom images will be developed. The laborious manipulations currently necessary will be automated. Phosphorus experiments will be attempted after they have been simulated by proton imaging on special phantoms with multi-line spectra and by numerical simultaion. Coils must be built for all phosphorus work and new coils should enhance proton images of the breast and eye.

NMR光谱学和成像的原理将结合起来， 将光谱信息引入全身成像。 这将对质子（氢）和磷进行。 化学位移信息可以大大增加对比度， 质子图像显示病变没有看到它。当两者 常规和光谱质子图像显示病变， 光谱学总是提供化学信息， 存在于传统的图像中。 某些组织的形态学 例如肾脏和脑脊液，使用新化学品可能会更好地显示 移动加权灰度。 光谱学允许校正 由化学位移差异引起的令人讨厌的假象。 在 磷成像这些伪影会非常严重 光谱学可能是必需的而不是增强。 我们已经开发出有限的脂肪和水 0.35特斯拉的光谱成像能力。 这将是 扩展到更高的领域和其他物质将是 针对性地 从体模中确定像素相位的方法 图像将被开发。 那些费力的操作 目前需要自动化。 磷的实验将尝试后，他们已经 多线体模质子成像模拟 光谱和数值模拟。 线圈必须建立所有磷的工作和新的线圈 应该增强乳房和眼睛的质子图像。