SPECTROSCOPIC NUCLEAR MAGNETIC RESONANCE IMAGING

能谱核磁共振成像

• 批准号: 3188160
• 负责人: W DIXON
• 金额: $ 5.6万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-09-30 至 1988-08-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3188160
• 关键词: brain imaging /visualization /scanning; clinical biomedical equipment; diagnosis quality /standard; image enhancement; imaging /visualization /scanning; phantom model; phase change; radionuclide diagnosis; radiotracer; spinal cord imaging /visualization; tritium

Principles of NMR spectroscopy and imaging will be combined to introduce spectroscopic information into whole body imaging. This will be done for protons (hydrogen) and phosphorus. Chemical shift information can increase contrast greatly in proton images showing lesions not seen without it. When both conventional and spectroscopic proton images show a lesion, spectroscopy always provides chemical information which is not present in the conventional image. Morphology of some tissues such as kidney and CSF may be better shown using new chemical shift weighted gray scales. Spectroscopy allows correction of troublesome artifacts caused by chemical shift differences. In phosphorus imaging these artifacts will be so severe spectroscopy may be a necessity not an enhancement. We have already developed limited fat versus water spectroscopic imaging capability at 0.35 Tesla. This will be extended to higher fields and other substances will be targeted. The method of determining pixel phase from phantom images will be developed. The laborious manipulations currently necessary will be automated. Phosphorus experiments will be attempted after they have been simulated by proton imaging on special phantoms with multi-line spectra and by numerical simultaion. Coils must be built for all phosphorus work and new coils should enhance proton images of the breast and eye.

核磁共振波谱和成像的原理将结合在一起 将光谱信息引入全身成像。 这将对质子(氢)和磷进行。 化学位移信息可以大大增加对比度 质子图像显示没有它的损伤是看不见的。当两者都存在时 常规的和光谱的质子图像显示了一个损伤， 光谱学总是提供化学信息，而不是 以传统的形象呈现。几种组织的形态 例如肾脏和脑脊液，使用新的化学物质可能会更好地显示 平移加权灰度级。光谱学允许校正 化学位移差异造成的麻烦的人工制品。在……里面 磷成像这些人工产物将是如此严重 光谱可能是一种必需品，而不是一种增强。 我们已经形成了有限的脂肪和水分 0.35特斯拉的光谱成像能力。这将是 扩展到更高的领域和其他物质将是 有针对性的。由体模确定像元相位的方法 图像将被冲洗出来。费力的操控 目前需要的将是自动化的。 磷实验将在它们完成后进行尝试 多谱线特殊体模的质子成像模拟 谱图和数值模拟。 必须为所有的磷工作和新的盘管建造盘管 应该增强胸部和眼睛的质子图像。