miRBase: the microRNA database

miRBase：微小RNA数据库

• 批准号: BB/M011275/1
• 负责人: Sam Griffiths-Jones
• 金额: $ 74.97万
• 依托单位: University of Manchester
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2015
• 资助国家: 英国
• 起止时间: 2015 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FM011275%2F1
• 关键词: miRBase; microRNA; database

MicroRNAs are tiny RNA sequences that are found in the cells of all animals and plants. Their role is to regulate the production of proteins from other genes in the genome - it is predicted that the 2500 known microRNAs in the human genome regulate around two thirds of the 20000-25000 human genes, for example. MicroRNAs have been shown to be important in essentially all functions in the cell and in a large number of diseases, including cancer and neurodegenerative disorders. MicroRNAs were only discovered to be so widespread in 2001. The miRBase database was established soon after to catalog microRNAs as they are discovered, and to provide a range of services to the microRNA community. For example, miRBase assigns names to new microRNA discoveries, to ensure that the same microRNA is referred to by the same name in different publications. miRBase also acts as the central resource from which the most up-to-date set of microRNAs can always be retrieved, together with their locations in the genome, the methods by which they were found, the scientific publications that describe them, and links to other databases that contain related information. These functions have helped the microRNA field to grow at a tremendous rate. In 2013 alone, there were 8400 scientific publications about microRNAs. miRBase currently contains entries on 35828 microRNAs in 223 species.miRBase is used by essentially every microRNA researcher in the world. These users include those who study the roles of microRNAs in disease and other cellular processes, but also companies who make kits and resources to allow experimental biologists to detect and manipulate microRNAs. The miRBase website is used by around 40000-50000 different users each month, and miRBase has been mentioned in over 8000 scientific publications.The work that will be carried out under this proposal will ensure the continued availability of the essential functions of the miRBase database. It will also provide for the next phase of development of the resource. In particular, we will develop web tools that allow microRNA researchers to access and use the huge quantities of microRNA data that are being produced by so-called deep sequencing methods. We will also expand the database to include information about the genes that are regulated by microRNAs, again from deep sequencing data.

MicroRNA 是在所有动物和植物细胞中发现的微小 RNA 序列。它们的作用是调节基因组中其他基因的蛋白质产生——例如，据预测，人类基因组中的 2500 个已知 microRNA 调节着 20000-25000 个人类基因中的大约三分之二。 MicroRNA 已被证明对细胞的几乎所有功能和许多疾病（包括癌症和神经退行性疾病）都很重要。直到 2001 年，人们才发现 MicroRNA 如此广泛。不久之后就建立了 miRBase 数据库，对发现的 microRNA 进行编目，并为 microRNA 社区提供一系列服务。例如，miRBase 为新的 microRNA 发现分配名称，以确保相同的 microRNA 在不同的出版物中以相同的名称引用。 miRBase 还充当中心资源，从中始终可以检索最新的 microRNA 集，以及它们在基因组中的位置、发现它们的方法、描述它们的科学出版物以及包含相关信息的其他数据库的链接。这些功能帮助 microRNA 领域以惊人的速度发展。仅 2013 年，就有 8400 篇有关 microRNA 的科学出版物。 miRBase 目前包含 223 个物种的 35828 个 microRNA 条目。世界上几乎每个 microRNA 研究人员都在使用 miRBase。这些用户包括那些研究 microRNA 在疾病和其他细胞过程中的作用的用户，也包括制造试剂盒和资源以允许实验生物学家检测和操作 microRNA 的公司。 miRBase 网站每月约有 40000-50000 名不同用户使用，并且 miRBase 已在 8000 多种科学出版物中提及。根据该提案将开展的工作将确保 miRBase 数据库基本功能的持续可用性。它还将为下一阶段的资源开发提供支持。特别是，我们将开发网络工具，使 microRNA 研究人员能够访问和使用通过所谓的深度测序方法产生的大量 microRNA 数据。我们还将扩展数据库，以包含有关受 microRNA 调控的基因的信息，这些信息同样来自深度测序数据。

项目成果

The embryonic transcriptome of Parhyale hawaiensis reveals different dynamics of microRNAs and mRNAs during the maternal-zygotic transition.

• DOI: 10.1038/s41598-021-03642-9
• 发表时间: 2022-01-07
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Calvo L;Birgaoanu M;Pettini T;Ronshaugen M;Griffiths-Jones S
• 通讯作者: Griffiths-Jones S

MicroRNA evolution, expression, and function during short germband development in Tribolium castaneum.

• DOI: 10.1101/gr.193367.115
• 发表时间: 2016-01
• 期刊: Genome research
• 影响因子: 7
• 作者: Ninova M;Ronshaugen M;Griffiths-Jones S
• 通讯作者: Griffiths-Jones S