2021-BBSRC/NSF-BIO An autonomous registry system for plant microRNAs

2021-BBSRC/NSF-BIO 植物 microRNA 自主注册系统

• 批准号: BB/W018438/1
• 负责人: Sam Griffiths-Jones
• 金额: $ 59.82万
• 依托单位: University of Manchester
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FW018438%2F1
• 关键词: 2021; BBSRC; NSF; BIO; autonomous

MicroRNAs tiny RNAs that function to regulate other genes in animals and plants. In plants, microRNAs are involved in many biological processes, including development of different plant tissues, and the mechanisms by which plants adapt and respond to stress. In crops, microRNAs have been found to be involved in fertility and yield, and are therefore important molecules to understand for food and agriculture. The past two decades have seen the discovery of thousands of different microRNA genes. When a new microRNA is discovered, it is vital that it is catalogued, named, and information about it made available to the scientific community. A single central registry and database has existed since 2004 to name and catalogue microRNAs: miRBase (https://www.mirbase.org/). However, the processes by which microRNAs have been named and catalogued have been, until now, time-consuming and labour-intensive. Recently, the pace at which microRNAs have been discovered has overwhelmed the capacity of miRBase to deal with them. Yet the need for a single trusted resource is more acute than ever.This proposal aims to design and implement a system by which new microRNAs are automatically assessed for the quality of their annotation, named, and deposited in the public miRBase database, focussing first on plant microRNAs. The tools that we produce to annotate new microRNAs will be made freely and publicly available, such that all microRNA biologists can use the same standards for microRNA discovery. This work will therefore enable the continued expansion of the microRNA field.

MicroRNA 微小的 RNA，其功能是调节动物和植物中的其他基因。在植物中，microRNA 参与许多生物过程，包括不同植物组织的发育，以及植物适应和响应胁迫的机制。在农作物中，microRNA 被发现与生育力和产量有关，因此是粮食和农业领域需要了解的重要分子。在过去的二十年里，我们发现了数千种不同的 microRNA 基因。当发现新的 microRNA 时，对其进行编目、命名并向科学界提供相关信息至关重要。自 2004 年以来，已经存在一个用于命名和编目 microRNA 的中央注册表和数据库：miRBase (https://www.mirbase.org/)。然而，到目前为止，microRNA 的命名和编目过程一直是耗时且费力的。最近，microRNA 的发现速度已经超过了 miRBase 的处理能力。然而，对单一可信资源的需求比以往任何时候都更加迫切。该提案旨在设计和实现一个系统，通过该系统自动评估新 microRNA 的注释质量、命名并存储在公共 miRBase 数据库中，首先关注植物 microRNA。我们生产的用于注释新 microRNA 的工具将免费公开提供，以便所有 microRNA 生物学家都可以使用相同的标准来发现 microRNA。因此，这项工作将使 microRNA 领域不断扩大。