210 POLONIUM RADIATION AND DITHIOLS

钚是一种具有放射性的氡子体。它是一个阿尔法发射器， 因此，如果允许进入人体，就会有危险。对于男性来说，吸入和 摄取是进入的主要途径。曾经有过一些“灾难” 由210Po事故引起，例如英国的WindScale事故。 铀矿工人的职业危险之一是吸入210Po。 最近，人们对大气中的氡和210Po浓度感到担忧 通风不良的建筑物和家庭的室内空气由 用于场地准备和/或建筑材料的材料。在……里面 此外，核设施也发生了210Po的事故。 这个实验室的一个小的初步实验的结果表明 无论是DMSA还是DMPA，都是水溶性的，而且较少 BAL的有毒类似物，保护大鼠免受亚急性致死剂量210Po的伤害。 我们的目标是确认和扩大初步初审的结果 实验，以确定BAL类似物是否将210Po从 对辐射敏感的组织(如脾)对辐射不敏感的组织 (例如肌肉)，以确定这些二硫醇是否增加210Po的排泄和 为了确定BAL和其毒性较低的类似物在拯救生命方面是否不同 给予致死剂量的210钚的大鼠的活动。 这些研究有助于评估辐射对活体造成的损害。 采矿环境中存在阿尔法排放者，在一些较差的环境中 核设施和其他设施中通风的工作场所和房屋 环境。此外，它还可以提供实验信息。 给在接触阿尔法排放物后不得不治疗人类的医生。

210Polonium is a radioactive daughter of radon. It is an alpha emitter and thus hazardous if allowed to enter the body. For man, inhalation and ingestion are the major portals of entry. There have been "disasters" caused by accidents with 210Po, e.g. the Windscale accident in England. One of the occupational dangers of uranium miners is 210Po inhalation. There has been recent concern about radon and 210Po concentrations in the interior air of poorly ventilated buildings and homes resulting from materials used in site preparation and/or construction materials. In addition, accidents in nuclear facilities have occurred with 210Po. The results of a small preliminary experiment in this laboratory indicate that the administration of either DMSA or DMPA, water soluble and less toxic analogs of BAL, protects rats from a subacute lethal dose of 210Po. Our aims are to confirm and expand the results of the initial preliminary experiment, to determine whether BAL analogs redistribute 210Po from radiation sensitive tissue (e.g. spleen) to radiation insensitive tissues (e.g. muscle), to determine if these dithiols increase 210Po excretion and to determine whether BAL and its less toxic analogs differ in life-saving activity in rats given a lethal dose of 210Polonium. These studies can help evaluate the damage done to a living body by the presence of alpha emitters in mining environments, in some poorly ventilated work places and houses, in nuclear facilities and other environments. In addition, it can make experimental information available to physicians who have to treat humans after exposure to alpha emitters.