CHARACTERIZATION OF INDUCED NEUROENDOCRINE LUNG CANCER

诱发神经内分泌肺癌的特征

• 批准号: 3191897
• 负责人: Hildegard M. Schuller
• 金额: $ 14.52万
• 依托单位: UNIVERSITY OF TENNESSEE KNOXVILLE
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-07-01 至 1991-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3191897
• 关键词: cellular oncology; chemical carcinogen; chemical carcinogenesis; disease /disorder model; environment related neoplasm /cancer; hamsters; histochemistry /cytochemistry; histopathology; hyperoxia; immunochemistry; lung neoplasms; model design /development; molecular oncology; neoplasm /cancer genetics; neuroendocrine system; nitrosamines; oncogenes; preneoplastic state; small cell lung cancer; tobacco abuse

Neuroendocrine lung cancer is one of the most common types of cancer in smokers but has never been induced in an animal. This project is based on the discovery that simultaneous exposure of hamsters to hyperoxia and diethylnitrosamine (DEN) induces a high incidence of neuroendocrine lung cancers while hyperoxia alone, or DEN alone lead to a pronounced increase of pulmonary endocrine cells. This unique in vivo model is of potentially great importance for studies into mechanisms of development of this poorly understood malignancy as well as chemopreventive and therapeutic investigations. However, a prerequisite for all such research is an in-depth characterization of the tumors. The specific aims of this project are: To study the pathology, neuroendocrinology and molecular biology of neuroendocrine lung tumors induced in Syrian golden hamsters by exposure to hyperoxia and DEN and to correlate pathological changes with alterations in neuroendocrine and genetic markers during tumor development.

神经内分泌型肺癌是肺癌最常见的类型之一。 在吸烟者身上致癌，但从未在动物身上诱导过。这 该项目的基础是发现同时曝光的 仓鼠对高氧和二乙基亚硝胺(DEN)的反应 高氧血症时神经内分泌型肺癌的高发 单独使用或单独使用DEN会显著增加肺活量 内分泌细胞。这种独特的活体模型具有很大的潜在价值 对其发展机制进行研究的重要性 对恶性肿瘤以及化学预防和治疗知之甚少 治疗性调查。然而，所有这些的先决条件 研究是对肿瘤的深入表征。这个 这个项目的具体目的是：研究病理学， 神经内分泌学与神经内分泌肺的分子生物学 染毒诱发叙利亚金黄地鼠肿瘤 高氧血症与DEN及其相关病理改变 肿瘤发生过程中神经内分泌和遗传标志物的变化 发展。