Ambulatory microdialysis sampling system

布里斯托大学的斯塔福德·莱特曼教授开发了一种医疗设备，用于每天24小时（包括在不受干扰的睡眠期间）从受试者那里进行常规样本的微创自动收集。这将首次使人们能够对一天中已知变化的临床和生物分析物进行详细研究。该设备在基础研究、动物和人类疾病的预后和诊断、临床试验和药物开发以及治疗监测方面具有潜在的应用。该项目将通过开发一个更加用户友好的设备的预生产原型来提供商业原理证明，该原型足够灵活，可以用于一系列研究场景，并且足够坚固，可以用于大型动物以及人体。这将经过全面测试和验证，并准备进行人体试验和CE认证。获得CE标志将为该设备作为研究工具销售铺平道路，无论是通过被许可人还是分拆公司。

Prof Stafford Lightman (Univ Bristol) has developed a medical device for the minimally invasive automated collection of regular samples from a subject 24 hours a day, including during undisturbed sleep. For the first time, this will enable the detailed study of clinical and biological analytes known to vary over the day. The device has potential applications in basic research, for prognosis and diagnosis of disease in animals and man, in clinical trials and drug development and for therapeutic monitoring. This project will deliver commercial proof of principle by developing a pre-production prototype of the device which is more user-friendly, flexible enough to be used in a range of research scenarios, and robust enough to be used on large animals as well as in man. This will be fully tested and validated, and ready for trials in man and CE marking. Achievement of a CE mark will pave the way for the device to be sold as a research tool, either through a licensee or a spinout company.