Ambulatory microdialysis sampling system

流动微透析取样系统

• 批准号: BB/M019268/1
• 负责人: Stafford Lightman
• 金额: $ 22.86万
• 依托单位: University of Bristol
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2015
• 资助国家: 英国
• 起止时间: 2015 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FM019268%2F1
• 关键词: Ambulatory; microdialysis; sampling; system

Prof Stafford Lightman (Univ Bristol) has developed a medical device for the minimally invasive automated collection of regular samples from a subject 24 hours a day, including during undisturbed sleep. For the first time, this will enable the detailed study of clinical and biological analytes known to vary over the day. The device has potential applications in basic research, for prognosis and diagnosis of disease in animals and man, in clinical trials and drug development and for therapeutic monitoring. This project will deliver commercial proof of principle by developing a pre-production prototype of the device which is more user-friendly, flexible enough to be used in a range of research scenarios, and robust enough to be used on large animals as well as in man. This will be fully tested and validated, and ready for trials in man and CE marking. Achievement of a CE mark will pave the way for the device to be sold as a research tool, either through a licensee or a spinout company.

斯塔福德·莱特曼教授（布里斯托尔大学）开发了一种医疗设备，可以每天24小时（包括在不受干扰的睡眠期间）从受试者身上自动采集常规样本。这将首次使临床和生物分析的详细研究能够在一天内变化。该设备在基础研究、动物和人类疾病的预后和诊断、临床试验和药物开发以及治疗监测方面具有潜在的应用前景。该项目将通过开发该设备的预生产原型来提供原理的商业证明，该设备更加用户友好，足够灵活，可用于一系列研究场景，并且足够坚固，可用于大型动物和人类。这将进行充分的测试和验证，并准备在人类和CE标志中进行试验。获得CE标志将为该设备作为研究工具销售铺平道路，无论是通过被许可方还是通过衍生公司。

项目成果

High-resolution daily profiles of tissue adrenal steroids by portable automated collection

通过便携式自动采集获得组织肾上腺类固醇的高分辨率每日概况

• DOI: 10.1126/scitranslmed.adg8464
• 发表时间: 2023
• 期刊: Science Translational Medicine
• 影响因子: 17.1
• 作者: Upton T