QUANTITATIVE EVALUATION OF CLINICAL HYPERTHERMIA

临床热疗的定量评估

• 批准号: 3195912
• 负责人: C-K. CHOU
• 金额: $ 12.09万
• 依托单位: CITY OF HOPE NATIONAL MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-04-01 至 1994-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3195912
• 关键词: antineoplastics; bone marrow; bone marrow neoplasms; computer simulation; disease /disorder model; dosage; hamsters; human therapy evaluation; laboratory mouse; neoplasm /cancer thermotherapy; thermometry; thermostability

The ability to quantify thermal dosage is essential if hyperthermia is to be used for the treatment of cancer. However, no acceptable method yet exists. The solution to this problem demands major advances in two areas: a) the accurate three dimensional measurement (or calculation) of tissue temperatures (temperature mapping) and b) the conversion of these measurements into a treatment description which is a predictor of response. While the first area is beyond the scope of this project, the goal of this proposal is to address the second of these problems by furthering the development of a clinically useful means of calculating thermal dose from time and temperature information gathered during hyperthermia therapy. Towards this goal, a simple thermal dose calculating method was developed and described by the principal investigator. A number of clinical reports, both in human trials and in trials on spontaneous tumors in pet animals have shown that this method is predictive of response and may be the best approach available. This proposal is directed toward improving and adapting this approach to account for some of the factors which are known to influence thermal effects and will also attempt to investigate alternative means of quantifying thermal treatments. These directions are reflected in the following four specific aims: 1) The first aim is to further develop thermal iso-effect dose concepts and calculations to account for the phenomena of a) step-down heating, b) thermal adaptation and c) thermotolerance. To this end, in vitro data will be obtained to provide the information necessary for the mathematical description of these phenomena. In vivo testing of these improvements will be performed using murine normal bone marrow and tumors. 2) The second aim is to investigate the time-temperature relationship when hyperthermia is combined with radiation or chemotherapeutic agents. 3) The third aim is to investigate the importance of spatial distribution of thermal dose in the response to clinical treatment and to evaluate methods of describing the spatial distribution of dose by using a murine tumor system where predictable thermal gradients can be reproduced. 4) The fourth aim is to develop, distribute and maintain a Hyperthermia Data File Standard format and computer programs which can be used to evaluate dose models by any institution with actual clinical data.

如果要进行热疗，量化热剂量的能力至关重要 可用于治疗癌症。 但目前还没有可以接受的方法 存在。 解决这个问题需要在两个方面取得重大进展： a) 组织的精确三维测量（或计算） 温度（温度映射）和 b）这些的转换 将测量结果纳入治疗描述，这是反应的预测因子。 虽然第一个领域超出了该项目的范围，但该项目的目标 建议通过进一步解决第二个问题 开发一种临床上有用的方法来计算热剂量 热疗期间收集的时间和温度信息。 为了实现这一目标，开发了一种简单的热剂量计算方法 并由首席研究员描述。 多项临床报告， 在人体试验和宠物自发性肿瘤试验中 已经表明这种方法可以预测反应并且可能是最好的 可用的方法。 该提案旨在改进和 调整这种方法来考虑一些已知的因素 影响热效应，还将尝试研究 量化热处理的替代方法。 这些方向是 体现在以下四个具体目标： 1）第一个目标是 进一步发展热等效应剂量概念和计算 考虑 a) 降压加热，b) 热适应现象 c) 耐热性。 为此，将获得体外数据 提供数学描述所需的信息 现象。 这些改进的体内测试将使用 小鼠正常骨髓和肿瘤。 2）第二个目的是调查 热疗与热疗结合时的时间-温度关系 放射或化疗药物。 3）第三个目的是调查 热剂量空间分布在响应中的重要性 临床治疗并评估描述空间的方法 在可预测的情况下使用鼠肿瘤系统进行剂量分布 可以再现热梯度。 4）第四个目标是发展， 分发和维护热疗数据文件标准格式以及 可用于评估任何剂量模型的计算机程序 具有实际临床数据的机构。