ELECTROCHEMICAL TREATMENT OF TUMORS WITH DC CURRENT

直流电电化学治疗肿瘤

• 批准号: 2284822
• 负责人: C-K. CHOU
• 金额: $ 1.03万
• 依托单位: CITY OF HOPE NATIONAL MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-09-30 至 1995-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2284822
• 关键词: alternative medicine; combination cancer therapy; cooperative study; disease /disorder model; dosage; electrical property; electrochemistry; histology; human subject; laboratory mouse; laboratory rat; neoplasm /cancer chemotherapy; neoplasm /cancer immunology; neoplasm /cancer radiation therapy; neoplasm /cancer therapy; nonhuman therapy evaluation

DESCRIPTION (Adapted from Applicant's Abstract): Electrochemical treatment (ECT) of cancer involves inserting platinum anodes into the center of a tumor and platinum cathodes into the tumor periphery.A direct current is maintained between the anodes and cathodes for 30 minutes to several hours, for a dose of 100 coulombs per cubic centimeter. Dr. Xin Yu-ling of China summarized the results of 2516 cases from 66 hospitals at the 1st International Symposium on Electrochemotherapy of Cancer Tumors in Beijing October 20-30, 1992. The primary cases were cancer of the lungs, liver, skin and breast. In addition, 18 other types of tumors were treated.This method is especially suitable for elderly or weak patients who are unable to endure surgery, radiation or chemotherapy.The ECT method was shown to be very effective for superficial tumors and was comparable to or better than conventional surgery, radiation or chemotherapy for deep tumors.This alternative method is simple and economical. In order to make this method available for patients in the United States, basic research must be conducted before it can be clinically tested.In collaboration with the Chinese scientists, pilot studies were designed to obtain preliminary results for quantifying dose response relationships in animals. Mechanisms of tumor response would be studied by measuring changes in a cellular environment. In future large scale studies, inter- disciplinary research would be conducted combining expertise in electrical engineering, physiology, biochemistry, cell biology, immunology, pathology, chemotherapy and radiation. The engineering study would investigate tumor tissue conductivity, current distribution and electrode configuration.The treatment method would be standardized so that results from different hospitals can be compared. Biological studies would quantify dose response relationships in tumors of various sizes. Physiological and histological effects would be studied. Immune response to ECT would be examined in detail. Combinations of ECT with radiation and chemotherapy would be explored. Laboratory results would be used to design clinical protocols. The goal is to make electrochemical treatment a useful method for fighting cancer.

描述（改编自申请人摘要）：电化学

项目成果

Electrochemical treatment of mouse and rat fibrosarcomas with direct current

• DOI: 10.1002/(sici)1521-186x(1997)18:1<14::aid-bem4>3.0.co;2-8
• 发表时间: 1997-01-01
• 期刊: BIOELECTROMAGNETICS
• 影响因子: 1.9
• 作者: Chou, CK;McDougall, JA;Vora, N
• 通讯作者: Vora, N

Electrochemical treatment of human KB cells in vitro.

• DOI: 10.1002/(sici)1521-186x(1999)20:1
• 发表时间: 1999
• 期刊: Bioelectromagnetics
• 影响因子: 1.9
• 作者: Yun Yen;Jian Ren Li;Bing Sen Zhou;Fernando Rojas;Jonathan Yu;Chung-Kwang Chou