ELECTROCHEMICAL TREATMENT OF TUMORS WITH DC CURRENT

描述(改编自申请人的摘要)：电化学 癌症的治疗(ECT)包括将铂阳极插入到 肿瘤中心和铂阴极进入肿瘤外围。 在阳极和阴极之间保持直流电30 几分钟到几个小时，每立方体100库仑的剂量 厘米。中国辛玉玲博士总结2516年的研究成果 来自66家医院的病例在首届国际学术研讨会上的发言 1992年10月20-30日在北京开展的肿瘤电化学治疗。 主要病例为肺癌、肝癌、皮肤癌和乳腺癌。在……里面 此外，还治疗了18种其他类型的肿瘤。 特别适合年长或身体虚弱、无法忍受的患者 手术、放疗或化疗。ECT方法被证明是非常有效的 对浅表肿瘤有效，可与之媲美或优于 深部肿瘤的常规手术、放疗或化疗。 另一种方法简单、经济。为了做到这一点 在美国，患者可以使用的方法，基础研究必须 在可以进行临床测试之前进行。与 中国科学家的先导研究旨在获得初步的 量化动物体内剂量反应关系的结果。 肿瘤反应的机制将通过测量 蜂窝环境。在未来的大规模研究中， 学科研究将结合以下方面的专业知识进行 电气工程、生理学、生物化学、细胞生物学、 免疫学、病理学、化疗和放射治疗。工程学 研究将调查肿瘤组织的电导率、电流分布 和电极配置。处理方法将标准化 这样就可以比较不同医院的结果。生物学 研究将量化不同类型肿瘤的剂量反应关系 大小。将研究生理和组织学效应。免疫 将详细审查对ECT的反应。将ECT与 将探索放射和化疗。实验室结果将会 用于设计临床方案。其目标是使电化学 治疗是抗击癌症的有效方法.

DESCRIPTION (Adapted from Applicant's Abstract): Electrochemical treatment (ECT) of cancer involves inserting platinum anodes into the center of a tumor and platinum cathodes into the tumor periphery.A direct current is maintained between the anodes and cathodes for 30 minutes to several hours, for a dose of 100 coulombs per cubic centimeter. Dr. Xin Yu-ling of China summarized the results of 2516 cases from 66 hospitals at the 1st International Symposium on Electrochemotherapy of Cancer Tumors in Beijing October 20-30, 1992. The primary cases were cancer of the lungs, liver, skin and breast. In addition, 18 other types of tumors were treated.This method is especially suitable for elderly or weak patients who are unable to endure surgery, radiation or chemotherapy.The ECT method was shown to be very effective for superficial tumors and was comparable to or better than conventional surgery, radiation or chemotherapy for deep tumors.This alternative method is simple and economical. In order to make this method available for patients in the United States, basic research must be conducted before it can be clinically tested.In collaboration with the Chinese scientists, pilot studies were designed to obtain preliminary results for quantifying dose response relationships in animals. Mechanisms of tumor response would be studied by measuring changes in a cellular environment. In future large scale studies, inter- disciplinary research would be conducted combining expertise in electrical engineering, physiology, biochemistry, cell biology, immunology, pathology, chemotherapy and radiation. The engineering study would investigate tumor tissue conductivity, current distribution and electrode configuration.The treatment method would be standardized so that results from different hospitals can be compared. Biological studies would quantify dose response relationships in tumors of various sizes. Physiological and histological effects would be studied. Immune response to ECT would be examined in detail. Combinations of ECT with radiation and chemotherapy would be explored. Laboratory results would be used to design clinical protocols. The goal is to make electrochemical treatment a useful method for fighting cancer.