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ANIHWA call 2: Better bone quality in laying hens

ANIHWA 呼吁 2：蛋鸡骨骼质量更好

基本信息

批准号：
BB/M028291/1
负责人：
Ian Dunn
金额：
$ 24.11万
依托单位：
University of Edinburgh
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2015
资助国家：
英国
起止时间：
2015 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=BB%2FM028291%2F1
关键词：
ANIHWA call Better bone quality

项目摘要

Laying hens can produce eggs economically for over a year; a highly digestible protein that has done much to improve world nutrition. However the long period of egg production can come with correlated problems of bone pathology. During egg laying oestrogen induces the formation of medullary bone, a form of calcium storage, in the cavities of the long bones. This bone is highly labile and turns over rapidly during shell formation. The bone forming osteoblasts are almost exclusively active during the formation of medullary bone during lay; however the osteoclasts, which reabsorb the medullary bone for calcium transport to the shell gland, act also on the structural cortical bone. This results in weaker bones (osteoporosis) and susceptibility to bone fracture. Non-cage systems exacerbate the problem with increases in bone fracture and keel bone deformities (>50%). With the demand for economical food unlikely to reduce, solutions to improve bone health are required.We have shown that there is the genetic potential within commercial pure lines to both lay a high number of eggs and have good bone quality. However the method of assessment of bone quality relies on killing the birds, which precludes subsequent breeding. To counter this, we have developed a number of approaches to discover genetic markers and we have identified a metabolic marker which explains variance in bone quality. Our aim will be to validate these markers and develop a novel phenotypic measurement for bone quality which does not require killing the hen.The project will build on studies recently completed or under way to detect genetic markers which predict bone quality which have been confined to one line of hens. The study will use quasi static strength measurement, density measurement as well as analytical techniques (infrared spectrometry, 2D X-ray diffraction) to study the chemistry and structure of bone to give a comprehensive insight in to factors defining bone phenotype. These populations, which will be from two types of hen, will be used to validate the markers for use in selection. The populations will also be used to validate the new phenotypic tool (quantitative axial ultrasound) and for the measurement of the blood metabolite which we have shown to be correlated to bone density. By using an array of approaches we expect to deliver practical solutions to breeders that will allow the genetic potential of laying hens with better bone to be realised.

蛋鸡可以经济地生产一年多的鸡蛋;一种高度消化的蛋白质，为改善世界营养做了很多工作。然而，长时间的产卵可能会带来骨病理学的相关问题。在产卵期间，雌激素诱导髓骨的形成，这是一种在长骨腔中储存钙的形式。这种骨头非常不稳定，在壳形成期间迅速翻转。成骨细胞几乎只在产蛋过程中的髓骨形成过程中活跃;然而，破骨细胞（其重吸收髓骨以将钙转运至壳腺）也作用于结构性皮质骨。这会导致骨骼变弱（骨质疏松症）和易骨折。非融合器系统使问题恶化，骨折和龙骨畸形增加（>50%）。随着对经济食品的需求不太可能减少，需要改善骨骼健康的解决方案。我们已经证明，商业纯系中存在遗传潜力，既可以产大量卵，又具有良好的骨骼质量。然而，评估骨骼质量的方法依赖于杀死鸟类，这排除了随后的繁殖。为了解决这个问题，我们已经开发了许多方法来发现遗传标记，我们已经确定了一种代谢标记，可以解释骨质的差异。我们的目标是验证这些标记，并开发一种新的骨质量表型测量方法，而不需要杀死母鸡。该项目将建立在最近完成或正在进行的研究基础上，以检测预测骨质量的遗传标记，这些标记仅限于一个系的母鸡。该研究将使用准静态强度测量，密度测量以及分析技术（红外光谱法，2D X射线衍射）来研究骨的化学和结构，以全面了解定义骨表型的因素。这些群体将来自两种类型的母鸡，将用于验证用于选择的标记。这些人群还将用于验证新的表型工具（定量轴向超声）和测量血液代谢物，我们已经证明血液代谢物与骨密度相关。通过使用一系列方法，我们希望为育种者提供实用的解决方案，使具有更好骨骼的蛋鸡的遗传潜力得以实现。

项目成果

期刊论文数量（10）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Additional file 3 of An eQTL in the cystathionine beta synthase gene is linked to osteoporosis in laying hens

胱硫醚β合酶基因中的 eQTL 与蛋鸡骨质疏松症相关的附加文件 3

DOI：
10.6084/m9.figshare.11896113
发表时间：
2020
期刊：
影响因子：
0
作者：
Dirk-Jan Koning
通讯作者：
Dirk-Jan Koning

Additional file 4 of An eQTL in the cystathionine beta synthase gene is linked to osteoporosis in laying hens

胱硫醚β合酶基因中的 eQTL 与蛋鸡骨质疏松症相关的附加文件 4

DOI：
10.6084/m9.figshare.11896122
发表时间：
2020
期刊：
影响因子：
0
作者：
Dirk-Jan Koning
通讯作者：
Dirk-Jan Koning

SCN9A variant in a family of mixed breed dogs with congenital insensitivity to pain.

DOI：
10.1111/jvim.16610
发表时间：
2023-01
期刊：
JOURNAL OF VETERINARY INTERNAL MEDICINE
影响因子：
2.6
作者：
Gutierrez-Quintana, Rodrigo;Christen, Matthias;Faller, Kiterie M. E.;Guevar, Julien;Jagannathan, Vidhya;Leeb, Tosso
通讯作者：
Leeb, Tosso

Increasing persistency in lay and stabilising egg quality in longer laying cycles. What are the challenges?