14IBCAT1FEASIBILITY - Engineering a Nano-factory for Peptide Synthesis

14IBCAT1可行性 - 设计用于肽合成的纳米工厂

• 批准号: BB/M028186/1
• 负责人: Steven Burston
• 金额: $ 11.63万
• 依托单位: University of Bristol
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2015
• 资助国家: 英国
• 起止时间: 2015 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FM028186%2F1
• 关键词: 14IBCAT1FEASIBILITY; Engineering; Nano; factory; Peptide

Peptides are short chains of simple chemical building blocks called amino acids. They are involved in numerous key biological processes including acting as toxins, pigments, drugs and hormones. They also control many of the most important cellular functions in animals, plants and man, and are used as tools in scientific research. There is considerable worldwide interest in developing new methods of producing peptides in sufficient quantity and of sufficient quality for use as pharmaceuticals, agrochemicals or research tools. The current favoured method for manufacturing peptides involves using chemical agents to fuse together the amino acid building blocks that form them. This approach is time-consuming, expensive, generates toxic waste products, and cannot be applied to many unusual but valuable peptides. In this project we will develop a new method of producing peptides which is not limited by these major problems. We will use an engineered peptide 'nano-factory', which when introduced into bacteria allows them to produce significant quantities of high value 'difficult' peptides without any of the problems or complexities associated with chemical synthesis.

肽是由称为氨基酸的简单化学结构单元组成的短链。它们参与许多关键的生物过程，包括充当毒素、色素、药物和激素。它们还控制着动物、植物和人类中许多最重要的细胞功能，并被用作科学研究的工具。全世界对开发生产足够数量和足够质量的肽以用作药物、农用化学品或研究工具的新方法有相当大的兴趣。目前最受欢迎的制造肽的方法包括使用化学试剂将形成肽的氨基酸构建块融合在一起。这种方法耗时，昂贵，产生有毒废物，并且不能应用于许多不寻常但有价值的肽。在这个项目中，我们将开发一种新的生产肽的方法，它不受这些主要问题的限制。我们将使用一种工程肽“纳米工厂”，当引入细菌时，它可以使细菌产生大量高价值的“困难”肽，而不会产生任何与化学合成相关的问题或复杂性。