CogChip: development of a targeted genotyping chip for executive function

CogChip：开发用于执行功能的靶向基因分型芯片

• 批准号: LP160101592
• 负责人: Prof Mark Bellgrove
• 金额: $ 38.75万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-12-20 至 2022-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP160101592
• 关键词: CogChip; development; targeted; genotyping; chip

This project aims to use DNA sequencing technology to identify the genetics of executive function. Our capacities to focus on a task at hand, to filter distractions and to inhibit unwanted impulses, are collectively referred to as executive functions. Executive function varies on a continuum in the general population across the lifespan, with individual differences largely due to differences in underlying genetics. The project proposes to leverage this knowledge to develop a customised genotyping chip, which may find application for prediction of individual differences in executive ability across multiple settings including education and industry. Expected outcomes for the project will include breakthrough insights into the biology of cognition, and a genetic read-out of individual differences in executive ability, which could have broad application including the potential to facilitate the targeting of cognitive, educational or workplace training for those most at risk of adverse outcomes.

本项目旨在利用DNA测序技术来确定执行功能的遗传学。我们专注于手头任务的能力，过滤干扰和抑制不必要的冲动，统称为执行功能。在一般人群中，执行功能在整个生命周期中是连续变化的，个体差异主要是由于潜在遗传学的差异。该项目建议利用这些知识来开发定制的基因分型芯片，该芯片可以用于预测包括教育和工业在内的多种环境中执行能力的个体差异。该项目的预期成果将包括对认知生物学的突破性见解，以及对执行能力个体差异的遗传读数，这可能具有广泛的应用，包括促进针对那些最有可能出现不良结果的人进行认知，教育或工作场所培训的潜力。