SENSORY ALTERATIONS OF CRANIOFACIAL FORM

颅面形态的感官改变

• 批准号: 3219483
• 负责人: ARTHUR J MILLER
• 金额: $ 21.38万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 1981
• 资助国家: 美国
• 起止时间: 1981-02-01 至 1987-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3219483
• 关键词: electromyography; mandible /maxilla; muscle contraction; neural information processing; neuromuscular function; oral facial restoration; physiologic bone resorption; respiratory function; sensorimotor system; striated muscles; tongue; touch

This project has three specific aims: 1) Extending the study on determining the effects of altered proprioceptive feedback on the neuromuscular system and craniofacial morphology in response to tactile stimulation of the tongue; 2) Determine what characteristics of programmed sensory stimulation may modify craniofacial muscles and cranioskeleton; 3) Determine the direct effect of chronic motor nerve stimulation on the cranioskeleton. Rhesus monkeys will be used as the experimental animal and electrodes will be chronically implanted within the mesencephalic trigeminal nucleus to synaptically recruit motor neurons of the trigeminal motor system, and directly within the motor nucleus. The stimulus will be applied at two different frequencies (i.e. 5/sec continuously and 30/sec for 10 sec of every minute) for the same total number of pulses to unilaterally recuit mandibular elevator muscles and the digastric muscle. The stimulation will be applied by a free running constant current pulse generator. Muscles will be analyzed by electromyography, histochemistry and computer tomography to ascertain long-term changes in the neuromuscular system to specific stimulation parameters. The cranioskeleton will be analyzed by standard radiographs and computer tomography to ascertain for the long-term changes which are expected to occur within 12 months. The long-term objectives of the proposal are to determine what characteristics of active muscle recruitment in terms of frequency of discharge, level of discharge and total duration, will modify bone density or reshape the bone. The project is based on the concept that muscle has specific properties that modify bone and that these specific properties reside in the active recruitment of motor units at a certain frequency and intensity. The project emphasizes that craniofacial muscles are one key factor in reshaping some aspects of the mandible. The interaction between form and function is important in the field of orthodontic treatment, growth and development of the craniofacial region, and orthopedics, and this project focuses on those aspects of muscle which might relate to bone reshaping.

本项目有三个具体目标：1）将研究扩展到 确定改变的本体感受反馈对 神经肌肉系统和颅面形态对触觉的反应 刺激舌头; 2）确定编程的特征 感觉刺激可以改变颅面肌肉和颅骨骼; 3） 确定慢性运动神经刺激对 颅骨 实验动物为恒河猴， 电极将被长期植入中脑内 三叉神经核突触募集三叉神经运动神经元 运动系统，并直接在运动核内。 刺激措施将是 以两种不同的频率施加（即，连续5次/秒和30次/秒 每分钟10秒），对于相同的脉冲总数， 单侧牵开下颌升肌和二腹肌。 将通过自由运行的恒定电流脉冲施加刺激 生成器. 肌肉将通过肌电图、组织化学 和计算机断层扫描来确定神经肌肉的长期变化 系统到特定刺激参数。 头骨会 通过标准射线照片和计算机断层扫描分析，以确定 预计在12个月内发生的长期变化。 该提案的长期目标是确定 主动肌肉募集的频率特征 放电水平和总持续时间将改变骨密度 或者重塑骨骼 该项目是基于肌肉具有 改变骨骼的特性，这些特性 存在于运动单位以一定频率的主动募集中， 强度。 该项目强调，颅面肌肉是一个关键 在重塑下颌骨的某些方面的因素。 之间的相互作用 形式和功能在正牙治疗领域中是重要的， 颅面区域的生长和发育，以及整形外科， 这个项目的重点是那些可能与骨骼有关的肌肉方面 重塑